中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae

文献类型:期刊论文

作者Han, Jian1; Liu, Kechun2; Wang, Rongchun2; Zhang, Yun2; Zhou, Bingsheng1
刊名AQUATIC TOXICOLOGY
出版日期2019-09-01
卷号214期号:1页码:9
ISSN号0166-445X
关键词Cadmium Calcium Otolith development Locomotor and balance control Zebrafish embryos/larvae
DOI10.1016/j.aquatox.2019.105236
英文摘要

Otolith consisting largely of calcium carbonate, fibrous and proteins, is vital for maintaining body balance and/or hearing of fish. The formation of otolith involves Ca2+ transport and deposition. In the present study, we investigated the effects of Cd2+ on otoliths development by using zebrafish embryos as model. The results showed that exposure to Cd2+ inhibited the utricular and saccular otoliths growth, indicated by reduced lateral areas. Swimming speeds were reduced and a losing balance control was observed in Cd2+ exposed larvae. The genes related to Ca2+ transport (e.g. plasma membrane Ca2+ -ATPase isoform 2, pmca2; Ca2+ -ATPase isoform 2, atp2b1a) and regulation (e.g. parathyroid hormone ligand type-1, pth1; stanniocalcin isoform 1, stc1) were significantly downregulated. However, the adverse effects of Cd2+ on otoliths growth and swimming activity can be protected by supplementation of Ca2+ in exposure medium. Body burden of Cd2+ in larvae was reduced upon the supplement with Ca2+. The overall results suggest that exposure to Cd2+ can inhibit influx of Ca2+, leading to less deposition of CaCO3 for otolith growth, and finally result in impaired balance control and swimming activity in zebrafish larvae.

WOS关键词EXPRESSION ; NEUROMASTS ; ROUTES ; GROWTH
资助项目National Natural Science Foundation of China[21806091] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ03] ; Natural Science Foundation of Shandong Province[ZR2016YL009]
WOS研究方向Marine & Freshwater Biology ; Toxicology
语种英语
出版者ELSEVIER
WOS记录号WOS:000486357100002
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; 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National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; 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State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; 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源URL[http://ir.ihb.ac.cn/handle/342005/33529]  
专题水生生物研究所_水环境工程研究中心_期刊论文
通讯作者Han, Jian
作者单位1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Qilu Univ Technol, Shandong Acad Sci, Biol Inst, Jinan 250014, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Han, Jian,Liu, Kechun,Wang, Rongchun,et al. Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae[J]. AQUATIC TOXICOLOGY,2019,214(1):9.
APA Han, Jian,Liu, Kechun,Wang, Rongchun,Zhang, Yun,&Zhou, Bingsheng.(2019).Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae.AQUATIC TOXICOLOGY,214(1),9.
MLA Han, Jian,et al."Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae".AQUATIC TOXICOLOGY 214.1(2019):9.

入库方式: OAI收割

来源:水生生物研究所

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