Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients
文献类型：期刊论文
| 作者 | Xiong, Qian; Ge, Feng |
| 刊名 | EXPERT REVIEW OF PROTEOMICS
 |
| 出版日期 | 2011-08-01 |
| 卷号 | 8期号:4页码:439-442 |
| 关键词 | 2D-DIGE multiple myeloma predictive biomarkers thalidomide |
| ISSN号 | 1478-9450 |
| 通讯作者 | Ge, F (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China ; gefeng@ihb.ac.cn |
| 中文摘要 | Predicting response to thalidomide-based therapy remains a challenging task faced by clinicians in the treatment of multiple myeloma. The pioneering work reported by Rajpal et al. moves one step further towards solving this challenge. They developed a proteomics-based approach that combines immunodepletion, 2D-difference gel electrophoresis analysis and mass spectrometry to search for serum proteins with expressions that show significant correlations to thalidomide treatment. This integrated approach allowed them to identify a panel of protein biomarkers. By using ELISA-based validation and strict statistical analysis, the authors have achieved an overall 84.0% predictive accuracy, with associated sensitivity and specificity values of 81.8 and 86.2%, respectively. Their methods and significant findings are reviewed within this article. This panel of biomarkers may not only guide initial therapy, but can also provide direct implications for personalized medicine in multiple myeloma patients. |
| 英文摘要 | Predicting response to thalidomide-based therapy remains a challenging task faced by clinicians in the treatment of multiple myeloma. The pioneering work reported by Rajpal et al. moves one step further towards solving this challenge. They developed a proteomics-based approach that combines immunodepletion, 2D-difference gel electrophoresis analysis and mass spectrometry to search for serum proteins with expressions that show significant correlations to thalidomide treatment. This integrated approach allowed them to identify a panel of protein biomarkers. By using ELISA-based validation and strict statistical analysis, the authors have achieved an overall 84.0% predictive accuracy, with associated sensitivity and specificity values of 81.8 and 86.2%, respectively. Their methods and significant findings are reviewed within this article. This panel of biomarkers may not only guide initial therapy, but can also provide direct implications for personalized medicine in multiple myeloma patients. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | QUANTITATIVE PROTEOMICS ; SYSTEMS BIOLOGY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000294139500008 |
| 公开日期 | 2011-11-09 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/16357]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 作者单位 | Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiong, Qian,Ge, Feng. Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients[J]. EXPERT REVIEW OF PROTEOMICS,2011,8(4):439-442. |
| APA | Xiong, Qian,&Ge, Feng.(2011).Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients.EXPERT REVIEW OF PROTEOMICS,8(4),439-442. |
| MLA | Xiong, Qian,et al."Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients".EXPERT REVIEW OF PROTEOMICS 8.4(2011):439-442. |
入库方式： OAI收割
来源：水生生物研究所
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