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A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain
文献类型：期刊论文
| 作者 | Liu, Xiang-Hong1,2; Tang, Xiao-Zhen2; Miao, Feng-Ping1 ; Ji, Nai-Yun1
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| 刊名 | NATURAL PRODUCT COMMUNICATIONS
 |
| 出版日期 | 2011-09-01 |
| 卷号 | 6期号:9页码:1243-1246 |
| 关键词 | 3-hydroxy-5-(hydroxymethyl)-4-(4 '-hydroxyphenoxy)pyrrolidin-2-one Gibberella zeae Fusarium graminearum Codium fragile |
| ISSN号 | 1934-578X |
| 产权排序 | [Liu, XH; Miao, FP; Ji, NY] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Liu, XH; Tang, XZ] Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271018, Shandong, Peoples R China |
| 通讯作者 | Ji, NY, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. nyji@yic.ac.cn |
| 中文摘要 | A new pyrrolidine derivative, 3-hydroxy-5-(hydroxymethyl)-4-(4'-hydroxyphenoxy)pyrrolidin-2-one (1), and eight known steroids, (22E,24R)-7 beta,8 beta-epoxy-3 beta,5 alpha,9 alpha-trihydroxyergosta-22-en-6-one (2, a reassigned structure of (22E,24R)-5 alpha,6 alpha-epoxy-3 beta,8 beta,14 alpha-trihydroxyergosta-22-en-7-one), (22E,24R)-3 beta,5 alpha,9 alpha-trihydroxyergosta-7,22-dien-6-one (3), (22E,24R)-3 beta,5 alpha-dihydroxyergosta-7,22-dien-6-one (4), (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (5), (22E,24R)-ergosta-5,22-dien-3 beta-ol (6), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (7), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (8), and (22E,24R)-1(10 -> 6)-abeo-ergosta-5,7,9,22-tetraen-3 alpha-ol (9), were isolated from the cultures of Gibberella zeae, an endophytic fungus isolated from the marine green alga Codium fragile. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. Compound 1 showed cytotoxicity against A-549 and BEL-7402 cell lines. |
| 英文摘要 | A new pyrrolidine derivative, 3-hydroxy-5-(hydroxymethyl)-4-(4'-hydroxyphenoxy)pyrrolidin-2-one (1), and eight known steroids, (22E,24R)-7 beta,8 beta-epoxy-3 beta,5 alpha,9 alpha-trihydroxyergosta-22-en-6-one (2, a reassigned structure of (22E,24R)-5 alpha,6 alpha-epoxy-3 beta,8 beta,14 alpha-trihydroxyergosta-22-en-7-one), (22E,24R)-3 beta,5 alpha,9 alpha-trihydroxyergosta-7,22-dien-6-one (3), (22E,24R)-3 beta,5 alpha-dihydroxyergosta-7,22-dien-6-one (4), (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (5), (22E,24R)-ergosta-5,22-dien-3 beta-ol (6), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (7), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (8), and (22E,24R)-1(10 -> 6)-abeo-ergosta-5,7,9,22-tetraen-3 alpha-ol (9), were isolated from the cultures of Gibberella zeae, an endophytic fungus isolated from the marine green alga Codium fragile. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. Compound 1 showed cytotoxicity against A-549 and BEL-7402 cell lines. |
| 学科主题 | Pharmacology & Pharmacy; Food Science & Technology |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Food Science & Technology |
| 关键词[WOS] | FUSARIUM-ROSEUM ATCC-28114 ; MINOR METABOLITES ; FRUIT BODIES ; CONSTITUENTS ; GRAMINEARUM |
| 收录类别 | SCI |
| 资助信息 | Chinese Academy of Sciences for Key Topics in Innovation Engineering[KZCX2-YW-QN209, KSCX2-EW-G-12B]; Shandong Province Natural Science Foundation[ZR2009BQ021]; Yantai Municipal Sci-Tech Development Program[2009164]; Foundation of the Chinese Academy of Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000294381500008 |
| 公开日期 | 2011-11-11 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/5114]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271018, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xiang-Hong,Tang, Xiao-Zhen,Miao, Feng-Ping,et al. A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain[J]. NATURAL PRODUCT COMMUNICATIONS,2011,6(9):1243-1246. |
| APA | Liu, Xiang-Hong,Tang, Xiao-Zhen,Miao, Feng-Ping,&Ji, Nai-Yun.(2011).A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain.NATURAL PRODUCT COMMUNICATIONS,6(9),1243-1246. |
| MLA | Liu, Xiang-Hong,et al."A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain".NATURAL PRODUCT COMMUNICATIONS 6.9(2011):1243-1246. |
入库方式： OAI收割
来源：烟台海岸带研究所
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