Copy number variation (CNV) in the IGF1R gene across four cattle breeds and its association with economic traits
文献类型：期刊论文
| 作者 | Ma, Yi-Lei; Wen, Yi-Fan; Cao, Xiu-Kai; Cheng, Jie; Huang, Yong-Zhen; Ma, Yun; Hu, Lin-Yong ; Lei, Chu-Zhao; Qi, Xing-Lei; Cao, Hui
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| 刊名 | ARCHIVES ANIMAL BREEDING
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| 出版日期 | 2019 |
| 卷号 | 62期号:1 |
| 英文摘要 | The insulin-like growth factor 1 receptor (IGF1R) plays a vital role in immunomodulation and muscle and bone growth. The copy number variation (CNV) is believed to the reason for many complex phenotypic variations. In this paper, we statistically analyzed the copy number and the expression profiling in different tissue types of the IGF1R gene using the 422 samples from four Chinese beef cattle breeds, and the mRNA of IGF1R was widely expressed in nine tissue types of adult cattle (heart, liver, kidney, muscle, fat, stomach, spleen, lung and testis). Results of CNV and growth traits indicated that the IGF1R CNV was significantly associated with body weight and body height of Jinnan (JN) cattle and was significantly associated with body height and hucklebone width of Qinchuan (QC) cattle, making IGF1R CNV a promising molecular marker to improve meat production in beef cattle breeding. Bioinformatics predictions show that the CNV region is highly similar to the human genome, and there are a large number of transcription factors, DNase I hypersensitive sites, and high levels of histone acetylation, suggesting that this region may play a role in transcriptional regulation, providing directions for further study of the role of bovine CNV and economic traits. |
| 源URL | [http://210.75.249.4/handle/363003/59817]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Ma, Yi-Lei,Wen, Yi-Fan,Cao, Xiu-Kai,et al. Copy number variation (CNV) in the IGF1R gene across four cattle breeds and its association with economic traits[J]. ARCHIVES ANIMAL BREEDING,2019,62(1). |
| APA | Ma, Yi-Lei.,Wen, Yi-Fan.,Cao, Xiu-Kai.,Cheng, Jie.,Huang, Yong-Zhen.,...&Chen, Hong.(2019).Copy number variation (CNV) in the IGF1R gene across four cattle breeds and its association with economic traits.ARCHIVES ANIMAL BREEDING,62(1). |
| MLA | Ma, Yi-Lei,et al."Copy number variation (CNV) in the IGF1R gene across four cattle breeds and its association with economic traits".ARCHIVES ANIMAL BREEDING 62.1(2019). |
入库方式： OAI收割
来源：西北高原生物研究所
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