Apigenin from daily vegetable celery can accelerate bone defects healing
文献类型：期刊论文
| 作者 | Jiang, Lei; Liu, Zenggen ; Cui, Yulei; Shao, Yun; Tao, Yanduo; Mei, Lijuan
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| 刊名 | JOURNAL OF FUNCTIONAL FOODS
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| 出版日期 | 2019 |
| 卷号 | 54 |
| 关键词 | Skull defect Celery Apigenin Mesenchymal stem cells Wnt |
| 英文摘要 | Apigenin, a natural compound in celery, is found to have pro-osteogenesis capacity by screening in our previous work. This study is focused on its pro-osteogenesis mechanism evaluation. The pro-osteogenesis effect of apigenin (50 mg/kg/day), was evaluated in skull defected (SD) mice by monitoring changes in bone histomor-phometry index, formation of new osteoblasts from MSCs and changes in the synthesis of pro-osteogenic cytokines. Signal pathways were investigated by QPCR, Western blot and immunofluorescence. Apigenin has significant pro-osteogenesis effect in vivo, which can promote osteoblasts formation, the expression of osteoblasts-specific marker genes and osteoblasts marker protein in vitro. From the perspective of molecular biology, apigenin promotes osteoblasts formation and the activation of Wnt pathway as well as the induction and nuclei translocation of beta-catenin. Driven by the results of this study, celery might be a useful alternative functional food in helping bone defects regeneration. |
| 源URL | [http://210.75.249.4/handle/363003/59841]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Jiang, Lei,Liu, Zenggen,Cui, Yulei,et al. Apigenin from daily vegetable celery can accelerate bone defects healing[J]. JOURNAL OF FUNCTIONAL FOODS,2019,54. |
| APA | Jiang, Lei,Liu, Zenggen,Cui, Yulei,Shao, Yun,Tao, Yanduo,&Mei, Lijuan.(2019).Apigenin from daily vegetable celery can accelerate bone defects healing.JOURNAL OF FUNCTIONAL FOODS,54. |
| MLA | Jiang, Lei,et al."Apigenin from daily vegetable celery can accelerate bone defects healing".JOURNAL OF FUNCTIONAL FOODS 54(2019). |
入库方式： OAI收割
来源：西北高原生物研究所
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