Design of a multifunctional biotinylated copper complex for visualization and quantification of cancer hypoxia levels
文献类型：期刊论文
| 作者 | Li, Zan; Zhu, Zhenzhu; Sun, Zhiwei; Ding, Jie; You, Jinmao
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| 刊名 | SENSORS AND ACTUATORS B-CHEMICAL
 |
| 出版日期 | 2019 |
| 卷号 | 282 |
| 关键词 | Cancer Copper complex Fluorescence visualization Quantification Hypoxia levels HIF-1 alpha suppression |
| 英文摘要 | Hypoxia, a typical hallmark of solid tumors, is associated closely with tumor progression and therapy resistance. Optical imaging has served as a powerful approach to study hypoxia in cancer cells. However, the noninvasive quantification of hypoxia levels in cancer cells is currently lacking. Herein, we report the design, synthesis, and biological evaluation of compound M, a novel fluorescence chemosensor to quantify hypoxia levels that relies on hypoxia-activated bioreduction. The remarkable selectivity and spectrum stability of compound M enabled us to visualize hypoxia and quantify the degree of hypoxia by high-throughput flow cytometry analysis in oxygen-deprived cancer cells. Furthermore, the HIF-1 alpha level suppression in cancer cells was achieved by compound M. With the realization of hypoxia levels quantification in a cobalt-treated hypoxia model, we envision that multifunctional compound M will find widespread applications in the study of physiological and pathological processes associated with hypoxia. |
| 源URL | [http://210.75.249.4/handle/363003/59850]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Li, Zan,Zhu, Zhenzhu,Sun, Zhiwei,et al. Design of a multifunctional biotinylated copper complex for visualization and quantification of cancer hypoxia levels[J]. SENSORS AND ACTUATORS B-CHEMICAL,2019,282. |
| APA | Li, Zan,Zhu, Zhenzhu,Sun, Zhiwei,Ding, Jie,&You, Jinmao.(2019).Design of a multifunctional biotinylated copper complex for visualization and quantification of cancer hypoxia levels.SENSORS AND ACTUATORS B-CHEMICAL,282. |
| MLA | Li, Zan,et al."Design of a multifunctional biotinylated copper complex for visualization and quantification of cancer hypoxia levels".SENSORS AND ACTUATORS B-CHEMICAL 282(2019). |
入库方式： OAI收割
来源：西北高原生物研究所
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