A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs
文献类型：期刊论文
| 作者 | Ma, Ji; Yin, Hongli; Li, Maoru; Deng, Yang; Ahmad, Owais; Qin, Guohong; He, Qiangqiang; Li, Jiajing; Gao, Kai; Zhu, Junyi |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
 |
| 出版日期 | 2019 |
| 卷号 | 15期号:5 |
| 关键词 | non-alcoholic fatty liver disease non-alcoholic steatohepatitis larval zebrafish high cholesterol diet |
| 英文摘要 | Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease around the world. However, there is still no drug for NAFLD in the market, the study of potential therapeutic drugs on NAFLD is extraordinarily pressing and urgent. The rodent models for NAFLD drugs' study are always with a long time cost. Therefore, we aim to establish a short-time NAFLD drug screening model. A laboratory-made high cholesterol diet was used on larval zebrafish for 3 weeks to establish the NAFLD screen model. Lipid metabolism, oxidant stress, and pathology were studied to comprehensively demonstrate the whole spectrum of NAFLD on this model. Bezafibrate and pioglitazone were used to evaluate the model. Moreover, mechanism research was performed on this model.The NAFLD larval zebrafish model was established with the comprehensive process of NAFLD. Moreover, multiple index on lipid metabolism, oxidant stress, hepatic steatosis, and hepatic inflammation can be easily tested for drug screening. Furthermore, this model can be used to perform the mechanism research by testing mRNA expression. The NAFLD larval zebrafish model is a comprehensive short-time screening method for NAFLD drugs. |
| 源URL | [http://210.75.249.4/handle/363003/59893]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Ma, Ji,Yin, Hongli,Li, Maoru,et al. A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2019,15(5). |
| APA | Ma, Ji.,Yin, Hongli.,Li, Maoru.,Deng, Yang.,Ahmad, Owais.,...&Shang, Jing.(2019).A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,15(5). |
| MLA | Ma, Ji,et al."A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 15.5(2019). |
入库方式： OAI收割
来源：西北高原生物研究所
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