Testosterone-retinoic acid signaling directs spermatogonial differentiation and seasonal spermatogenesis in the Plateau pika (Ochotona curzoniae)
文献类型：期刊论文
| 作者 | Wang, Yu Jun; Jia, Gong-Xue; Yan, Rong-Ge; Guo, Song-Chang; Tian, Fei ; Ma, Jian-Bin; Zhang, Rui-Na; Li, Cen; Zhang, Liang-Zhi; Du, Yu-Rong
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| 刊名 | THERIOGENOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 123 |
| 关键词 | Seasonal reproduction Spermatogenesis Testosterone Melatonin Retinoic acid |
| 英文摘要 | During evolution, animals optimize their reproductive strategies to increase offspring survival. Seasonal breeders reproduce only during certain times of the year. In mammals, reproduction is tightly controlled by hypothalamus-pituitary-gonad axis. Although pathways regulating gametogenesis in non-seasonal model species have been well established, molecular insights into seasonal reproduction are severely limited. Using the Plateau pika (Ochotona curzoniae), a small rodent animal species native to the Qinghai-Tibetan plateau, as a model, here we report that seasonal spermatogenesis is governed at the level of spermatogonial differentiation. In testis of the reproductively dormant animals, undifferentiated spermatogonia failed to differentiate and accumulated in the seminiferous tubules. RNA-seq analyses of the active and dormant testes revealed that genes modulating retinoic acid biogenesis and steriodogenesis were differentially regulated. A single injection of all-trans retinoic acid (ATRA) reinitiated spermatogenesis and inhibition the function of RA-degrading enzyme CYP26B1 for 10 days induced spermatogonial differentiation. Strikingly, testosterone injection reinitiated spermatogenesis in short day adapted animals. Testosterone provides a permissive environment of RA biogenesis and actions in testis, therefore, indirectly controls spermatogonial differentiation. Collectively, these findings provide a key mechanistic insight regarding the molecular regulation of seasonal reproduction in mammals. (C) 2018 Elsevier Inc. All rights reserved. |
| 源URL | [http://210.75.249.4/handle/363003/59910]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Yu Jun,Jia, Gong-Xue,Yan, Rong-Ge,et al. Testosterone-retinoic acid signaling directs spermatogonial differentiation and seasonal spermatogenesis in the Plateau pika (Ochotona curzoniae)[J]. THERIOGENOLOGY,2019,123. |
| APA | Wang, Yu Jun.,Jia, Gong-Xue.,Yan, Rong-Ge.,Guo, Song-Chang.,Tian, Fei.,...&Yang, Qi-En.(2019).Testosterone-retinoic acid signaling directs spermatogonial differentiation and seasonal spermatogenesis in the Plateau pika (Ochotona curzoniae).THERIOGENOLOGY,123. |
| MLA | Wang, Yu Jun,et al."Testosterone-retinoic acid signaling directs spermatogonial differentiation and seasonal spermatogenesis in the Plateau pika (Ochotona curzoniae)".THERIOGENOLOGY 123(2019). |
入库方式： OAI收割
来源：西北高原生物研究所
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