中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Over-expression of DEC1 inhibits myogenic differentiation by modulating MyoG activity in bovine satellite cell

文献类型:期刊论文

AuthorHuang, Yongzhen; Lai, Xinsheng; Hu, Linyong; Lei, Chuzhao; Lan, Xianyong; Zhang, Chunlei; Ma, Yun; Zheng, Li; Bai, Yue-Yu; Lin, Fengpeng
SourceJOURNAL OF CELLULAR PHYSIOLOGY
Issued Date2018
Volume233Issue:12
Keywordcattle DEC1 MyoG satellite cell skeletal muscle
English AbstractDifferentiated embryo chondrocyte 1 (DEC1), a member of basic-helix-loop-helix transcription factor Bhlhe40, also called stimulated by retinoic acid 13, STRA13, plays an important role in the regulation of adipogenesis, tumorigenesis, peripheral circadian output, response to hypoxia, and development of metabolic syndrome. Previous studies suggested that DEC1 was involved in skeletal muscle development; however, its precise role in myoblast differentiation has not been determined. In the present study, we showed that DEC1 expressed ubiquitously in different bovine tissues and was down-regulated in differentiated bovine satellite cells. Expression of muscle specific transcription factors (Myf5, MyoD, MyoG, and MHC) was significantly down-regulated when DEC1 was over-expressed by both CoCl2-simulated hypoxia and Adenovirus-mediated transduction in bovine satellite cells. Consistent with that, promoter analyses via luciferase reporter assay also revealed that overexpression of bovine DEC1 could inhibit MyoG promoter activity. In conclusion, overexpression of DEC1 blocked myogenesis by inhibiting MyoG promoter activity in bovine. Our results provided a new mechanism for the muscle growth, which would contribute to increase cattle meat productivity.
源URL[http://210.75.249.4/handle/363003/59924]  
Collection西北高原生物研究所_中国科学院西北高原生物研究所
Recommended Citation
GB/T 7714
Huang, Yongzhen,Lai, Xinsheng,Hu, Linyong,et al. Over-expression of DEC1 inhibits myogenic differentiation by modulating MyoG activity in bovine satellite cell[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2018,233(12).
APA Huang, Yongzhen.,Lai, Xinsheng.,Hu, Linyong.,Lei, Chuzhao.,Lan, Xianyong.,...&Chen, Hong.(2018).Over-expression of DEC1 inhibits myogenic differentiation by modulating MyoG activity in bovine satellite cell.JOURNAL OF CELLULAR PHYSIOLOGY,233(12).
MLA Huang, Yongzhen,et al."Over-expression of DEC1 inhibits myogenic differentiation by modulating MyoG activity in bovine satellite cell".JOURNAL OF CELLULAR PHYSIOLOGY 233.12(2018).

入库方式: OAI收割

来源:西北高原生物研究所

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