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Parental Exposure to Perfluorobutanesulfonate Impairs Offspring Development through Inheritance of Paternal Methylome

文献类型：期刊论文

作者Chen, Lianguo1; Tsui, Mirabelle M. P.2; Hu, Chenyan3; Wan, Teng4; Au, Doris W. T.4; Lam, James C. W.2,5; Lam, Paul K. S.2,4; Zhou, Bingsheng1
刊名ENVIRONMENTAL SCIENCE & TECHNOLOGY
出版日期2019-10-15
卷号53期号:20页码:12018-12025
ISSN号0013-936X
DOI10.1021/acs.est.9b03865
通讯作者Chen, Lianguo(lchenam@ihb.ac.cn)
英文摘要Perfluorobutanesulfonate (PFBS), an environmental pollutant of emerging concern, significantly impairs offspring development and overall health after parental exposure. However, the true inducer of offspring developmental defects among the complexity of parental influences remains unknown. In the present study, marine medaka (Oryzias melastigma) were exposed to environmentally realistic concentrations of PFBS (0, 1, 3, and 10 mu g/L) for an entire life cycle. By mixing and mating control and exposed medaka (male or female), a crossbreeding strategy was employed to produce offspring eggs from various crossbreeds, with the aim of differentiating the maternal and paternal influences. Measurements of swimming performance in larval offspring showed that larvae of exposed male parents swam hyperactively in comparison to the control larvae. Contrasting trends in PFBS transfer and maternal factor transfer (e.g., proteins and lipids) to that of swimming behavior eliminated these two factors as major inducers of offspring developmental impairment. Inheritance of the exposed paternal methylome marks in offspring may be partially responsible for abnormal swimming behavior, although different toxic mechanisms may be involved depending on the exposure concentration. Overall, these findings suggest that inheritance of epigenetic modifications implicates a long-lasting threat of PFBS to the fitness and sustainability of fish populations.
WOS关键词EPIGENETIC TRANSGENERATIONAL ACTIONS ; MATERNAL TRANSFER ; GENOME ; PERFLUOROALKYL ; SUBSTANCES ; PERFLUOROOCTANESULFONATE ; EXPRESSION ; RESPONSES ; BEHAVIOR ; REVEALS
资助项目Research Grants Council Theme-Based Research Scheme[T21-602/16-R] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB14040103] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ03] ; Dean's Research Fund from The Education University of Hong Kong
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000491219800043
资助机构Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong ; Dean's Research Fund from The Education University of Hong Kong
源URL[http://ir.ihb.ac.cn/handle/342005/34414]  
专题水生生物研究所_水环境工程研究中心_期刊论文
通讯作者Chen, Lianguo
作者单位1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
3.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430072, Hubei, Peoples R China
4.City Univ Hong Kong, Dept Chem, Kowloon, Hong Kong, Peoples R China
5.Educ Univ Hong Kong, Dept Sci & Environm Studies, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Lianguo,Tsui, Mirabelle M. P.,Hu, Chenyan,et al. Parental Exposure to Perfluorobutanesulfonate Impairs Offspring Development through Inheritance of Paternal Methylome[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2019,53(20):12018-12025.
APA Chen, Lianguo.,Tsui, Mirabelle M. P..,Hu, Chenyan.,Wan, Teng.,Au, Doris W. T..,...&Zhou, Bingsheng.(2019).Parental Exposure to Perfluorobutanesulfonate Impairs Offspring Development through Inheritance of Paternal Methylome.ENVIRONMENTAL SCIENCE & TECHNOLOGY,53(20),12018-12025.
MLA Chen, Lianguo,et al."Parental Exposure to Perfluorobutanesulfonate Impairs Offspring Development through Inheritance of Paternal Methylome".ENVIRONMENTAL SCIENCE & TECHNOLOGY 53.20(2019):12018-12025.

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来源：水生生物研究所

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