Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes
文献类型：期刊论文
| 作者 | Wu, Xiao Man1,4; Cao, Lu1,4; Nie, Pin1,2,4; Chang, Ming Xian1,2,3,4 |
| 刊名 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| 出版日期 | 2019-12-01 |
| 卷号 | 101页码:11 |
| ISSN号 | 0145-305X |
| 关键词 | Zebrafish histone H2A RIP2 Bacterial infection Antibacterial genes MHC-Related genes |
| DOI | 10.1016/j.dci.2019.103455 |
| 通讯作者 | Chang, Ming Xian(mingxianchang@ihb.ac.cn) |
| 英文摘要 | An octamer consisting of two copies of histones H2A, H2B, H3 and H4 is the nucleosome core. It is well established that histone derived antimicrobial peptides (AMPs) have anti-microbial properties in various invertebrate and vertebrate species. Different from well-known histone H2A-derived AMPs, the antimicrobial properties of the complete histone H2A are rather limited. In the present study, we report the functional characterization of the complete histone H2A from zebrafish. The expression of zebrafish histone H2A was higher in embryos than in larvae, and inducible in response to bacterial infection. Furthermore, the expression of zebrafish histone H2A was decreased by RIP2 deficiency with and/or without bacterial infection. During Edwardsiella piscicida infection, the overexpression of zebrafish histone H2A inhibited bacterial proliferation and increased the survival rate of zebrafish larvae. The overexpression of zebrafish histone H2A demonstrated an increased transcription of many antibacterial genes and MHC related genes, which was dependent on RIP2, an adaptor protein for signal propagation of the NLRs-mediated antibacterial immune response. In line with this, zebrafish histone H2A cooperated with RIP2 to induce the transcription of many antibacterial genes and MHC related genes. All together, these results firstly demonstrate the antibacterial property of the complete histone H2A against gram-negative bacteria E. piscicida in vivo and the correlation between zebrafish histone H2A and RIP2 adaptor protein on the transcriptional regulation of antibacterial genes and MHC related genes. |
| WOS关键词 | ANTIMICROBIAL PEPTIDE ; PARASIN-I ; PROMOTER ACTIVITY ; SKIN SECRETIONS ; RAINBOW-TROUT ; PROTEIN ; APOPTOSIS ; RESPONSES ; ISOFORMS ; DYNAMICS |
| 资助项目 | National Natural Science Foundation of China[31873046] ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China[2018CFA011] ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ04] |
| WOS研究方向 | Fisheries ; Immunology ; Zoology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000488141600011 |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund for State Key Laboratory of Freshwater Ecology and Biotechnology |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/34385]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 通讯作者 | Chang, Ming Xian |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China 2.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Hubei, Peoples R China 3.Chinese Acad Sci, Innovat Acad Seed Design, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Xiao Man,Cao, Lu,Nie, Pin,et al. Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2019,101:11. |
| APA | Wu, Xiao Man,Cao, Lu,Nie, Pin,&Chang, Ming Xian.(2019).Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,101,11. |
| MLA | Wu, Xiao Man,et al."Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 101(2019):11. |
入库方式： OAI收割
来源：水生生物研究所
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