中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Generalizability of machine learning for classification of schizophrenia based on resting-state functional MRI data

文献类型:期刊论文

作者Cai, Xin-Lu1,2,3; Xie, Dong-Jie1,4; Madsen, Kristoffer H.3,5,6; Wang, Yong-Ming1,2,3; Bogemann, Sophie Alida1,2,3; Cheung, Eric F. C.7; Moller, Arne3,8,9; Chan, Raymond C. K.1,2,3,10
刊名HUMAN BRAIN MAPPING
出版日期2019-10-01
页码13
关键词generalizability machine learning reproducibility schizophrenia spectrum disorders
ISSN号1065-9471
DOI10.1002/hbm.24797
产权排序1
文献子类Article
英文摘要

Machine learning has increasingly been applied to classification of schizophrenia in neuroimaging research. However, direct replication studies and studies seeking to investigate generalizability are scarce. To address these issues, we assessed within-site and between-site generalizability of a machine learning classification framework which achieved excellent performance in a previous study using two independent resting-state functional magnetic resonance imaging data sets collected from different sites and scanners. We established within-site generalizability of the classification framework in the main data set using cross-validation. Then, we trained a model in the main data set and investigated between-site generalization in the validated data set using external validation. Finally, recognizing the poor between-site generalization performance, we updated the unsupervised algorithm to investigate if transfer learning using additional unlabeled data were able to improve between-site classification performance. Cross-validation showed that the published classification procedure achieved an accuracy of 0.73 using majority voting across all selected components. External validation found a classification accuracy of 0.55 (not significant) and 0.70 (significant) using the direct and transfer learning procedures, respectively. The failure of direct generalization from one site to another demonstrates the limitation of within-site cross-validation and points toward the need to incorporate efforts to facilitate application of machine learning across multiple data sets. The improvement in performance with transfer learning highlights the importance of taking into account the properties of data when constructing predictive models across samples and sites. Our findings suggest that machine learning classification result based on a single study should be interpreted cautiously.

WOS关键词COMPUTER-AIDED DIAGNOSIS ; CONNECTIVITY PATTERNS ; TEMPORAL GYRUS ; NETWORK ; ONSET ; ABNORMALITIES ; METAANALYSIS ; BIOMARKERS ; MOVEMENT ; FEATURES
资助项目Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; National Key Research and Development Programme[2016YFC0906402] ; National Natural Science Foundation of China[81571317] ; CAS key Laboratory of Mental Health
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000488298800001
出版者WILEY
资助机构Beijing Municipal Science & Technology Commission Grant ; National Key Research and Development Programme ; National Natural Science Foundation of China ; CAS key Laboratory of Mental Health
源URL[http://ir.psych.ac.cn/handle/311026/30156]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Sinodanish Coll, Beijing, Peoples R China
3.Sinodanish Ctr Educ & Res, Beijing, Peoples R China
4.Zhejiang Normal Univ, Hangzhou Coll Presch Teacher Educ, Hangzhou, Zhejiang, Peoples R China
5.Univ Copenhagen, Hosp Hvidovre, Danish Res Ctr Magnet Resonance, Ctr Funct & Diagnost Imaging & Res, Copenhagen, Denmark
6.Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby, Denmark
7.Castle Peak Hosp, Hong Kong, Peoples R China
8.Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark
9.Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark
10.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Cai, Xin-Lu,Xie, Dong-Jie,Madsen, Kristoffer H.,et al. Generalizability of machine learning for classification of schizophrenia based on resting-state functional MRI data[J]. HUMAN BRAIN MAPPING,2019:13.
APA Cai, Xin-Lu.,Xie, Dong-Jie.,Madsen, Kristoffer H..,Wang, Yong-Ming.,Bogemann, Sophie Alida.,...&Chan, Raymond C. K..(2019).Generalizability of machine learning for classification of schizophrenia based on resting-state functional MRI data.HUMAN BRAIN MAPPING,13.
MLA Cai, Xin-Lu,et al."Generalizability of machine learning for classification of schizophrenia based on resting-state functional MRI data".HUMAN BRAIN MAPPING (2019):13.

入库方式: OAI收割

来源:心理研究所

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