When a Semiconductor Utilized as an NIR Laser-Responsive Photodynamic/Photothermal Theranostic Agent Integrates with Upconversion Nanoparticles
文献类型：期刊论文
| 作者 | Lv, Ruichan1; Wang, Yanxing1; Liu, Jun1; Feng, Miao1; Yang, Fan1; Jiang, Xue1; Tian, Jie1,2
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| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
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| 出版日期 | 2019-06-01 |
| 卷号 | 5期号:6页码:3100-3110 |
| 关键词 | donor-acceptor lanthanide doped semiconductor photodynamic therapy (PDT) |
| ISSN号 | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.9b00438 |
| 通讯作者 | Lv, Ruichan(rclv@xidian.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn) |
| 英文摘要 | Photoactive theranostics including photodynamic therapy (PDT) hace aroused an intensive interest that combines medical diagnostics with treatment under a single irradiation laser. However, the conventional organic PDT agents usually suffer from aggregation caused by the quenching effect. In this research, we designed a core-shell-shell (CSS) UCNPs with NaGdF4 as the host, and the UCNPs could emit higher blue/green light by the energy transfer processes among Nd/Yb/Tm/Gd/Tb under 808 nm laser. When the CSS UCNPs were combined with the MnO2 semiconductor as the energy acceptor, CSS@Mn could be utilized as an effective PDT agent under a NIR laser. The temperature also increased more than 12.2 degrees C under the 808 nm laser, indicating the potential of synergistic photothermal therapy (PTT) and PDT. Interestingly, cells with small amounts of H2O2 could be responsive to the CSS@Mn platform. The antitumor effect was proved by the in vitro and in vivo experiments. Also, the biocompatibility, biodistribution, and excretion pathway were detected and revealed by the H&E stained pathological section and photoacoustic (PA) images. That means this platform could be potentially used as antitumor PDT/PTT agents. |
| WOS关键词 | INFRARED QUANTUM DOTS ; SINGLET OXYGEN ; CANCER-THERAPY ; LIGHT ; NANOCRYSTALS ; DECOMPOSITION ; LUMINESCENCE ; GENERATION ; STRATEGY ; PROGRESS |
| 资助项目 | Natural Science Foundation of China[NSFC 81801744] ; Natural Science Foundation of China[81227901] ; National Key R&D Program of China[2017YFA0205202] ; Fundamental Research Funds for the Central Universities[XJS17011] ; Fundamental Research Funds for the Central Universities[JBX181202] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000471212300040 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | Natural Science Foundation of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://ir.ia.ac.cn/handle/173211/26024]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Lv, Ruichan; Tian, Jie |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Ruichan,Wang, Yanxing,Liu, Jun,et al. When a Semiconductor Utilized as an NIR Laser-Responsive Photodynamic/Photothermal Theranostic Agent Integrates with Upconversion Nanoparticles[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2019,5(6):3100-3110. |
| APA | Lv, Ruichan.,Wang, Yanxing.,Liu, Jun.,Feng, Miao.,Yang, Fan.,...&Tian, Jie.(2019).When a Semiconductor Utilized as an NIR Laser-Responsive Photodynamic/Photothermal Theranostic Agent Integrates with Upconversion Nanoparticles.ACS BIOMATERIALS SCIENCE & ENGINEERING,5(6),3100-3110. |
| MLA | Lv, Ruichan,et al."When a Semiconductor Utilized as an NIR Laser-Responsive Photodynamic/Photothermal Theranostic Agent Integrates with Upconversion Nanoparticles".ACS BIOMATERIALS SCIENCE & ENGINEERING 5.6(2019):3100-3110. |
入库方式： OAI收割
来源：自动化研究所
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