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Cognitive Decline Before and After Incident Coronary Events

文献类型：期刊论文

作者Xie, Wuxiang1,2; Zheng, Fanfan3,4; Yan, Li2; Zhong, Baoliang5
刊名JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
出版日期2019-06-25
卷号73期号:24页码:3041-3050
关键词cognitive decline coronary heart disease English Longitudinal Study of Ageing linear mixed model
ISSN号0735-1097
DOI10.1016/j.jacc.2019.04.019
通讯作者Xie, Wuxiang(xiewuxiang@hsc.pku.edu.cn)
英文摘要BACKGROUND Previous studies have suggested that coronary heart disease (CHD) may be associated with accelerated cognitive decline. However, the temporal pattern of cognitive decline before and after incident CHD remains largely unknown. OBJECTIVES The purpose of this study was to determine the cognitive trajectory before and after incident CHD diagnosis in a national representative cohort age >= 50 years. METHODS This study included 7,888 participants (mean age 62.1 +/- 10.2 years) with no history of stroke or incident stroke during follow-up from the English Longitudinal Study of Ageing. Participants underwent a cognitive assessment at baseline (wave 1, 2002 to 2003), and at least 1 other time point (from wave 2 [2004 to 2005] to wave 8 [2016 to 2017]). Incident CHD was identified as a diagnosis of myocardial infarction and/or angina during follow-up. RESULTS Incident CHD was associated with accelerated cognitive decline during a median follow-up of 12 years. The annual rate of cognitive decline before CHD diagnosis among individuals who experienced incident CHD was similar to that of participants who remained CHD-free throughout follow-up. No short-term cognitive decline was observed in participants with CHD diagnosis after the event. In the years following CHD diagnosis, global cognition, verbal memory, and temporal orientation scores declined significantly faster than they did before the event, after multivariable adjustment. Sensitivity analyses yielded similar results. CONCLUSIONS Incident CHD is associated with accelerated cognitive decline after, but not before, the event. Attention should be drawn to the long-term cognitive deterioration related to CHD. Careful monitoring of cognitive function is warranted in CHD patients in the years following the event. (C) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
WOS关键词VASCULAR-DISEASE ; RISK-FACTORS ; IMPAIRMENT ; DEMENTIA ; STROKE ; POPULATION ; LIFE ; AGE
资助项目National Natural Science Foundation of China[81601176] ; Beijing Natural Science Foundation[7182108] ; Newton International Fellowship from the Academy of Medical Sciences[NIF001-1005-P56804]
WOS研究方向Cardiovascular System & Cardiology
语种英语
WOS记录号WOS:000471773400002
出版者ELSEVIER SCIENCE INC
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Newton International Fellowship from the Academy of Medical Sciences
源URL[http://ir.ia.ac.cn/handle/173211/26073]  
专题自动化研究所_脑网络组研究中心
通讯作者Xie, Wuxiang
作者单位1.Peking Univ, Hlth Sci Ctr, Clin Res Inst, 38 Xueyuan Rd, Beijing 100191, Peoples R China
2.Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus,Norfolk Pl, London W2 1PG, England
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
4.UCL, Inst Cognit Neurosci, London, England
5.Huazhong Univ Sci & Technol, Tongji Med Coll, Affiliated Wuhan Mental Hlth Ctr, Dept Geriatr Psychiat, Wuhan, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Xie, Wuxiang,Zheng, Fanfan,Yan, Li,et al. Cognitive Decline Before and After Incident Coronary Events[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,2019,73(24):3041-3050.
APA Xie, Wuxiang,Zheng, Fanfan,Yan, Li,&Zhong, Baoliang.(2019).Cognitive Decline Before and After Incident Coronary Events.JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,73(24),3041-3050.
MLA Xie, Wuxiang,et al."Cognitive Decline Before and After Incident Coronary Events".JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 73.24(2019):3041-3050.

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来源：自动化研究所

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