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Biological analysis of the deletion mutants of Staphylococcal enterotoxin C2

文献类型：期刊论文

作者Wang, XG ; Zhang, HW ; Xu, MK ; Liu, CX ; Zhang, CG
刊名APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
出版日期2009
卷号83期号:6页码:1077-1084
ISSN号0175-7598
关键词Staphylococcal enterotoxin C2 Superantigen activity Fever activity Immunotherapeutic agent
通讯作者Xu, MK, Chinese Acad Sci, Microbiol Grp, Inst Appl Ecol, Shenyang 110016, Peoples R China
中文摘要To investigate the functional domains involved in the biological activity of staphylococcal enterotoxin (SEC2), a series of SEC2 mutants were constructed. Deletion of the last 77 amino acids at the C-terminus of SEC2 did not affect its native superantigen and fever activities, and further removal of the C-terminal residues reduced SEC2 activities significantly. On the other hand, the mutants lacking 18 or more N-terminal residues severely impaired superantigen activity. These data indicated that the functional regions for the biological activities of SEC2 were confined to N-terminal domain, further implied that the proper three-dimensional structure of SEC2 is not needed for its biological activities. Our results deliver valuable information that it is possible to design new SEC2 immunotherapeutic agents which have the superantigen activity and low molecular weight for permeability.
学科主题Biotechnology & Applied Microbiology
资助信息Institute of Applied Ecology of the CAS [06LYQYC001, 08SBS111S3]
收录类别SCI
语种英语
WOS记录号WOS:000267679900010
公开日期2011-09-23
源URL[http://210.72.129.5/handle/321005/54107]  
专题沈阳应用生态研究所_沈阳应用生态研究所_期刊论文
推荐引用方式
GB/T 7714		 Wang, XG,Zhang, HW,Xu, MK,et al. Biological analysis of the deletion mutants of Staphylococcal enterotoxin C2[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2009,83(6):1077-1084.
APA Wang, XG,Zhang, HW,Xu, MK,Liu, CX,&Zhang, CG.(2009).Biological analysis of the deletion mutants of Staphylococcal enterotoxin C2.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,83(6),1077-1084.
MLA Wang, XG,et al."Biological analysis of the deletion mutants of Staphylococcal enterotoxin C2".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 83.6(2009):1077-1084.

入库方式： OAI收割

来源：沈阳应用生态研究所

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