Identification of ssDNA aptamers specific for anti-neuroexcitation peptide III and molecular modeling studies: Insights into structural interactions
文献类型：期刊论文
| 作者 | Zhu, J ; Wang, J ; Su, ZC ; Li, Q ; Cheng, MS ; Zhang, JH |
| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 31期号:9页码:1120-1128 |
| 关键词 | SELEX ssDNA aptamers homology modeling AutoDock |
| ISSN号 | 0253-6269 |
| 通讯作者 | Zhang, JH, Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, POB 17,103 Wenhua Rd, Shenyang, Liaoning Prov, Peoples R China |
| 中文摘要 | Twelve ssDNA aptamers specific for a novel recombinant anti-neuroexcitation peptide (ANEPIII) were identified using the SELEX method from a 79-nucleotide ssDNA pool to purify ANEPIII in a more efficient way. To further understand the binding modes between ssDNA and ANEPIII, fully flexible dinucleotides were docked onto the homology-modeled ANEPIII structure. AutoDocking identified favorable binding sites on ANEPIII for nucleotides, which was valuable for designing more potent ligands. |
| 学科主题 | Chemistry, Medicinal; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259364900007 |
| 公开日期 | 2011-09-23 |
| 源URL | [http://210.72.129.5/handle/321005/54379]  |
| 专题 | 沈阳应用生态研究所_沈阳应用生态研究所_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhu, J,Wang, J,Su, ZC,et al. Identification of ssDNA aptamers specific for anti-neuroexcitation peptide III and molecular modeling studies: Insights into structural interactions[J]. ARCHIVES OF PHARMACAL RESEARCH,2008,31(9):1120-1128. |
| APA | Zhu, J,Wang, J,Su, ZC,Li, Q,Cheng, MS,&Zhang, JH.(2008).Identification of ssDNA aptamers specific for anti-neuroexcitation peptide III and molecular modeling studies: Insights into structural interactions.ARCHIVES OF PHARMACAL RESEARCH,31(9),1120-1128. |
| MLA | Zhu, J,et al."Identification of ssDNA aptamers specific for anti-neuroexcitation peptide III and molecular modeling studies: Insights into structural interactions".ARCHIVES OF PHARMACAL RESEARCH 31.9(2008):1120-1128. |
入库方式： OAI收割
来源：沈阳应用生态研究所
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