alpha-shaped DNA loops induced by MutS
文献类型：期刊论文
| 作者 | Jia, YX ; Bi, LJ ; Li, F ; Chen, YY ; Zhang, CG ; Zhang, XE |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2008 |
| 卷号 | 372期号:4页码:618-622 |
| 关键词 | MMR MutS mismatch alpha-loop |
| ISSN号 | 0006-291X |
| 通讯作者 | Zhang, XE, Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China |
| 中文摘要 | DNA mismatch repair (MMR) is critical for the maintenance of genomic stability. MMR is initiated by recognition of DNA mismatches by the protein, MutS, which subsequently recruits downstream repair factors. To better understand the mechanism by which MutS identifies and specifically binds mismatched basepairs embedded in random DNA sequences, we monitored the interaction between MutS and DNA substrates using atomic force microscopy (AFM). An alpha-shaped DNA loop formed by the interaction between MutS and DNA, which was independent of whether or not a mismatch was present in the DNA substrate. These data indicate that MutS associates with DNA non-specifically and forms an alpha-loop interaction with the DNA substrate. in this conformation, MutS is able to scan two arms of DNA simultaneously for each MutS dimer formed. (C) 2008 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000257419500020 |
| 公开日期 | 2011-09-23 |
| 源URL | [http://210.72.129.5/handle/321005/54445]  |
| 专题 | 沈阳应用生态研究所_沈阳应用生态研究所_期刊论文 |
| 推荐引用方式 GB/T 7714 | Jia, YX,Bi, LJ,Li, F,et al. alpha-shaped DNA loops induced by MutS[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,372(4):618-622. |
| APA | Jia, YX,Bi, LJ,Li, F,Chen, YY,Zhang, CG,&Zhang, XE.(2008).alpha-shaped DNA loops induced by MutS.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,372(4),618-622. |
| MLA | Jia, YX,et al."alpha-shaped DNA loops induced by MutS".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 372.4(2008):618-622. |
入库方式： OAI收割
来源：沈阳应用生态研究所
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