Toxicity and distribution of tetrodotoxin-producing bacteria in puffer fish Fugu rubripes collected from the Bohai Sea of China
文献类型：期刊论文
| 作者 | Wu, ZL ; Yang, Y ; Xie, LP ; Xia, GL ; Hu, JC ; Wang, SJ ; Zhang, RQ |
| 刊名 | TOXICON
 |
| 出版日期 | 2005 |
| 卷号 | 46期号:4页码:471-476 |
| 关键词 | tetrodotoxin tetrodotoxin-producing bacteria Fugu rubripes |
| ISSN号 | 0041-0101 |
| 通讯作者 | Zhang, RQ, Tsing Hua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China |
| 中文摘要 | To investigate the relationship between the toxicity of puffer fish and the distribution of tetrodotoxin-producing bacteria in puffer fish Fugu rubripes collected from the Bohai Sea of China, bacteria were isolated from each organ (ovaries, livers, intestines and gallbladders) and screened for tetrodotoxin (TTX) production. 20 out of 36 isolated strains were found to produce TTX in vitro. In the organs of ovaries and livers whose toxicity is more potent than other organs, the number and toxicity of TTX-producing strains was greater than that of others. Most TTX-producing bacterial strains were identified as Bacillus spp. (19 strains) and Actinomycete spp. (1 strain) based on the morphological observation, physiological and biochemical characteristics and G+C content of DNA. The purified toxin was identified to be TTX by high performance liquid chromatography assay, thin-layer chromatography assay and electrospray ionization mass spectrometry analysis. Our results suggested that TTX-producing bacteria are closely related to the toxification of the puffer fish. More research is needed to elucidate the mechanism of TTX synthesis and the role of TTX in bacteria. (C) 2005 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Toxicology |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000232127100014 |
| 公开日期 | 2011-09-23 |
| 源URL | [http://210.72.129.5/handle/321005/55065]  |
| 专题 | 沈阳应用生态研究所_沈阳应用生态研究所_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wu, ZL,Yang, Y,Xie, LP,et al. Toxicity and distribution of tetrodotoxin-producing bacteria in puffer fish Fugu rubripes collected from the Bohai Sea of China[J]. TOXICON,2005,46(4):471-476. |
| APA | Wu, ZL.,Yang, Y.,Xie, LP.,Xia, GL.,Hu, JC.,...&Zhang, RQ.(2005).Toxicity and distribution of tetrodotoxin-producing bacteria in puffer fish Fugu rubripes collected from the Bohai Sea of China.TOXICON,46(4),471-476. |
| MLA | Wu, ZL,et al."Toxicity and distribution of tetrodotoxin-producing bacteria in puffer fish Fugu rubripes collected from the Bohai Sea of China".TOXICON 46.4(2005):471-476. |
入库方式： OAI收割
来源：沈阳应用生态研究所
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