Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review
文献类型：期刊论文
| 作者 | Long M(龙勉) ; Sato M; Lim CT; Wu JH; Adachi T; Inoue Y
|
| 刊名 | Cellular and Molecular Bioengineering
 |
| 出版日期 | 2011 |
| 卷号 | 4期号:3页码:327-339 |
| 通讯作者邮箱 | mlong@imech.ac.cn; sato@bml.mech.tohoku.ac.jp; ctlim@nus.edu.sg |
| 关键词 | Cellular Mechanics Molecular Biomechanics Experimental Techniques Theoretical Modeling Computations Fluid Shear-Stress Endothelial-Cell Proliferation Adhesive Dynamics Simulation Ligand Binding-Kinetics Glycoprotein-Ib-Alpha Von-Willebrand-Factor Molecular-Dynamics Mechanical-Stress Beta-Switch 2-Dimensional Kinetics |
| ISSN号 | 1865-5025 |
| 产权排序 | [Long, Mian] Chinese Acad Sci, Key Lab Micrograv, Ctr Biomech & Bioengn, Inst Mech, Beijing 100190, Peoples R China; [Sato, Masaaki] Tohoku Univ, Grad Sch Biomed Engn, Sendai, Miyagi 9808579, Japan; [Lim, Chwee Teck] Natl Univ Singapore, Div Bioengn, Dept Mech Engn, Mechanobiol Inst, Singapore 117576, Singapore; [Wu, Jianhua] S China Univ Technol, Inst Biomech, Sch Biosci & Bioengn, Guangzhou, Guangdong, Peoples R China; [Adachi, Taiji; Inoue, Yasuhiro] Kyoto Univ, Inst Frontier Med Sci, Kyoto, Japan |
| 通讯作者 | Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Ctr Biomech & Bioengn, Inst Mech, Beijing 100190, Peoples R China |
| 合作状况 | 国际 |
| 中文摘要 | Recent advances in micro- and nano-technologies and high-end computing have enabled the development of new experimental and modeling approaches to study biomechanics at the micro- and nano-scales that were previously not possible. These new cutting-edge approaches are contributing toward our understanding in emerging areas such as mechanobiology and mechanochemistry. Another important potential contribution lies in translational medicine, since biomechanical studies at the cellular and molecular levels have direct relevance in areas such disease diagnosis, nano-medicine and drug delivery. Thus, the developed experimental and modeling approaches are critical in elucidating important mechanistic insights in both basic sciences and clinical treatment. While it is hard to cover all the recent advances in this mini-review, we focus on several important approaches. For experimental techniques, we review the assays involving shear flow, cellular imaging, microbead, microcontact printing, and micropillars at the micro-scale, and micropipette aspiration, optical tweezers, parallel flow chamber, and atomic force microscopy at the nano-scale. In modeling and simulations, we outline the theoretical modeling for actin dynamics in migrating cell and actin-based cell motility in cellular mechanics, as well as the receptor-ligand binding in cell adhesion and the application of free, steered, and flow molecular dynamics simulations in molecular biomechanics. Relevant scientific issues and applications are also discussed. |
| 学科主题 | Cell Biology; Biophysics |
| 分类号 | Q4 |
| 类目[WOS] | Cell & Tissue Engineering ; Biophysics ; Cell Biology |
| 研究领域[WOS] | Cell Biology ; Biophysics |
| 关键词[WOS] | FLUID SHEAR-STRESS ; ENDOTHELIAL-CELL PROLIFERATION ; ADHESIVE DYNAMICS SIMULATION ; LIGAND BINDING-KINETICS ; GLYCOPROTEIN-IB-ALPHA ; VON-WILLEBRAND-FACTOR ; MOLECULAR-DYNAMICS ; MECHANICAL-STRESS ; BETA-SWITCH ; 2-DIMENSIONAL KINETICS |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1007/s12195-011-0183-x |
| 语种 | 英语 |
| WOS记录号 | WOS:000297866300002 |
| 公开日期 | 2012-04-01 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/45074]  |
| 专题 | 力学研究所_国家微重力实验室 |
| 推荐引用方式 GB/T 7714 | Long M,Sato M,Lim CT,et al. Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review[J]. Cellular and Molecular Bioengineering,2011,4(3):327-339. |
| APA | 龙勉,Sato M,Lim CT,Wu JH,Adachi T,&Inoue Y.(2011).Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review.Cellular and Molecular Bioengineering,4(3),327-339. |
| MLA | 龙勉,et al."Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review".Cellular and Molecular Bioengineering 4.3(2011):327-339. |
入库方式： OAI收割
来源：力学研究所
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