Down-regulation of heme oxygenase-1 by SVCV infection
文献类型：期刊论文
| 作者 | Yuan, Junfa1; Su, Nian2; Wang, Min1; Xie, Ping2; Shi, Zhengli3; Li, Lijuan1 |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2012-02-01 |
| 卷号 | 32期号:2页码:301-306 |
| 关键词 | SVCV HO-1 Common carp Heat-shock protein 32 Oxidative stress |
| ISSN号 | 1050-4648 |
| 通讯作者 | Li, LJ (reprint author), Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China |
| 中文摘要 | Heme oxygenase (HO-1) is a cytoprotective enzyme that plays a critical role in defending the body against oxidant-induced injury during inflammatory processes. In mammalian systems, viral infection or antigen expression can down-regulate the expression of HO-1. In turn, the induction of HO-1 or overexpression of HO-1 results in potent and direct antiviral activity that targets the replication of several mammalian viruses. In this study, the HO-1 gene of Cyprinus carpi was cloned, and the expression profile of HO-1 was investigated during spring viremia of carp virus (SVCV) infection. The results demonstrate that the expression of HO-1 was down-regulated during SVCV infection in the EPC cells and in common carp. These results indicated that SVCV infection could induce host oxidative stress, which may contribute to tissue injury in affect fish. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved. |
| 英文摘要 | Heme oxygenase (HO-1) is a cytoprotective enzyme that plays a critical role in defending the body against oxidant-induced injury during inflammatory processes. In mammalian systems, viral infection or antigen expression can down-regulate the expression of HO-1. In turn, the induction of HO-1 or overexpression of HO-1 results in potent and direct antiviral activity that targets the replication of several mammalian viruses. In this study, the HO-1 gene of Cyprinus carpi was cloned, and the expression profile of HO-1 was investigated during spring viremia of carp virus (SVCV) infection. The results demonstrate that the expression of HO-1 was down-regulated during SVCV infection in the EPC cells and in common carp. These results indicated that SVCV infection could induce host oxidative stress, which may contribute to tissue injury in affect fish. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 研究领域[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 关键词[WOS] | C VIRUS-REPLICATION ; APOPTOSIS ; STRESS ; INTERFERES ; DEFENSE ; PROTEIN ; INJURY |
| 收录类别 | SCI |
| 资助信息 | Ministry of Education of China[20100146120013]; National Natural Science Foundation of China[30700624] |
| 语种 | 英语 |
| WOS记录号 | WOS:000300751800008 |
| 公开日期 | 2012-04-01 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/16707]  |
| 专题 | 水生生物研究所_淡水生态学研究中心_期刊论文 |
| 作者单位 | 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Junfa,Su, Nian,Wang, Min,et al. Down-regulation of heme oxygenase-1 by SVCV infection[J]. FISH & SHELLFISH IMMUNOLOGY,2012,32(2):301-306. |
| APA | Yuan, Junfa,Su, Nian,Wang, Min,Xie, Ping,Shi, Zhengli,&Li, Lijuan.(2012).Down-regulation of heme oxygenase-1 by SVCV infection.FISH & SHELLFISH IMMUNOLOGY,32(2),301-306. |
| MLA | Yuan, Junfa,et al."Down-regulation of heme oxygenase-1 by SVCV infection".FISH & SHELLFISH IMMUNOLOGY 32.2(2012):301-306. |
入库方式： OAI收割
来源：水生生物研究所
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