In vivo studies on the immunotoxic effects of microcystins on rabbit
文献类型：期刊论文
| 作者 | Yuan, Gailing1; Xie, Ping1,2; Zhang, Xuezhen1; Tang, Rong1; Gao, Yu1; Li, Dapeng1; Li, Li1 |
| 刊名 | ENVIRONMENTAL TOXICOLOGY
 |
| 出版日期 | 2012-02-01 |
| 卷号 | 27期号:2页码:83-89 |
| 关键词 | microcystin-LR (MC-LR) immunotoxicity rabbit cytokine WBC |
| ISSN号 | 1520-4081 |
| 通讯作者 | Xie, P (reprint author), Huazhong Agr Univ, Coll Fisheries, Key Lab Freshwater Biodivers Conservat & Utilizat, Minist Agr, Wuhan 430070, Peoples R China |
| 中文摘要 | Microcystins (MCs) are the toxic molecules produced by common cyanobacterium in freshwater blooms. Their toxicities raise severe health issues in livestock and human beings. In current study, the immunotoxic effects of MC-LR were investigated in rabbit through evaluating the dynamics of white blood cell (WBC) numbers and cytokine production such as interleukin-3 (IL-3), IL-4, IL-6, interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha). MCs at the high dose (50 mu g MC-LReq kg-1) significantly induced increase in the WBC number but decrease in the Th1 (IFN-gamma, TNF-alpha) and Th2 (IL-3, IL-4, IL-6) production. In the low dose group(12.5 mu g MC-LReq kg-1), the number of WBC and the production of IFN-gamma, IFN-alpha, IL-4, IL-3, and IL-6 increased gradually in first 12 h, reach the peaks at 12 h, and dropped after 24 h. Significantly positive correlations were found between the cytokines production of IL-4 and IL-6, IFN-gamma and IFN-alpha, or IL-4 and IFN-gamma. In conclusion, MC-LR is able to disturb the rabbit immune system and there exists time-dose response relationship in the MC-LR-eliciting perturbation, which probably give a better insight into investigating the immunotoxicity mechanisms of MCs in vivo. (C) 2010 Wiley Periodicals, Inc. Environ Toxicol, 2012. |
| 英文摘要 | Microcystins (MCs) are the toxic molecules produced by common cyanobacterium in freshwater blooms. Their toxicities raise severe health issues in livestock and human beings. In current study, the immunotoxic effects of MC-LR were investigated in rabbit through evaluating the dynamics of white blood cell (WBC) numbers and cytokine production such as interleukin-3 (IL-3), IL-4, IL-6, interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha). MCs at the high dose (50 mu g MC-LReq kg-1) significantly induced increase in the WBC number but decrease in the Th1 (IFN-gamma, TNF-alpha) and Th2 (IL-3, IL-4, IL-6) production. In the low dose group(12.5 mu g MC-LReq kg-1), the number of WBC and the production of IFN-gamma, IFN-alpha, IL-4, IL-3, and IL-6 increased gradually in first 12 h, reach the peaks at 12 h, and dropped after 24 h. Significantly positive correlations were found between the cytokines production of IL-4 and IL-6, IFN-gamma and IFN-alpha, or IL-4 and IFN-gamma. In conclusion, MC-LR is able to disturb the rabbit immune system and there exists time-dose response relationship in the MC-LR-eliciting perturbation, which probably give a better insight into investigating the immunotoxicity mechanisms of MCs in vivo. (C) 2010 Wiley Periodicals, Inc. Environ Toxicol, 2012. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Environmental Sciences ; Toxicology ; Water Resources |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Toxicology ; Water Resources |
| 关键词[WOS] | CYANOBACTERIAL TOXINS ; HEPATOTOXIC MICROCYSTINS ; IMMUNE FUNCTION ; MESSENGER-RNA ; NITRIC-OXIDE ; CYTOKINES ; LR ; MACROPHAGES ; AERUGINOSA ; EXPRESSION |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30530170] |
| 语种 | 英语 |
| WOS记录号 | WOS:000299038900003 |
| 公开日期 | 2012-04-01 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/16719]  |
| 专题 | 水生生物研究所_淡水生态学研究中心_期刊论文 |
| 作者单位 | 1.Huazhong Agr Univ, Coll Fisheries, Key Lab Freshwater Biodivers Conservat & Utilizat, Minist Agr, Wuhan 430070, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Gailing,Xie, Ping,Zhang, Xuezhen,et al. In vivo studies on the immunotoxic effects of microcystins on rabbit[J]. ENVIRONMENTAL TOXICOLOGY,2012,27(2):83-89. |
| APA | Yuan, Gailing.,Xie, Ping.,Zhang, Xuezhen.,Tang, Rong.,Gao, Yu.,...&Li, Li.(2012).In vivo studies on the immunotoxic effects of microcystins on rabbit.ENVIRONMENTAL TOXICOLOGY,27(2),83-89. |
| MLA | Yuan, Gailing,et al."In vivo studies on the immunotoxic effects of microcystins on rabbit".ENVIRONMENTAL TOXICOLOGY 27.2(2012):83-89. |
入库方式： OAI收割
来源：水生生物研究所
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