Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction
文献类型：期刊论文
| 作者 | Yue J ; Li XY ; Mo GJ ; Wang R ; Huang YB ; Jing XB |
| 刊名 | macromolecules
 |
| 出版日期 | 2010 |
| 卷号 | 43期号:23页码:9645-9654 |
| 关键词 | HETEROBIFUNCTIONAL POLY(ETHYLENE OXIDE) DRUG-DELIVERY SYSTEMS MICHAEL-TYPE ADDITION CLICK CHEMISTRY SELECTIVE SYNTHESIS HYDROXYL GROUP L-LACTIDE MICELLES GLYCOL) NANOPARTICLES |
| ISSN号 | 0024-9297 |
| 通讯作者 | jing xb |
| 中文摘要 | two kinds of amphiphilic block copolymers, allyoxyl poly(ethylene glycol)-b-poly(l-lactide) and methoxyl poly(ethylene glycol)-b-poly(l-lactide-co-2-methyl-2-allyloxycarbonyl-propylene carbonate), were synthesized in a controllable manner. radical mediated thiol-ene reaction was utilized to modify these two precursor block copolymers with three model mercaptans. highly efficient and quantitative modification under uv light without adding any photoinitiators was observed by h-1 nmr spectra of the products collected at specific time points. the reaction rate was mainly dependent on molar ratio of thiol to vinyl in feeding. quantitative transformation of the vinyl groups in both block copolymers was realized in 0.5-2 h when using excessive thiol with respect to vinyl. using commercially available mercaptans, different functional groups were introduced into the block copolymers, thus realizing modular functionalization of target block copolymers. this method of functionalization effectively avoided traditional protection/deprotection procedures, thus greatly simplifying the process of functionalization. precipitation and dialysis procedures were proved efficient to eliminate excess mercaptans, thus endowing the material with good biocompatibility. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000284967000012 |
| 公开日期 | 2012-04-25 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/43253]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yue J,Li XY,Mo GJ,et al. Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction[J]. macromolecules,2010,43(23):9645-9654. |
| APA | Yue J,Li XY,Mo GJ,Wang R,Huang YB,&Jing XB.(2010).Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction.macromolecules,43(23),9645-9654. |
| MLA | Yue J,et al."Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction".macromolecules 43.23(2010):9645-9654. |
入库方式： OAI收割
来源：长春应用化学研究所
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