Applications of Ultrafiltration Mass Spectrometry in the Studies on Interaction Between Small Drug Molecule and Biological Target
文献类型：期刊论文
| 作者 | Zhou H ; Song FR ; Liu ZQ ; Liu SY |
| 刊名 | progress in chemistry
 |
| 出版日期 | 2010 |
| 卷号 | 22期号:11页码:2207-2214 |
| 关键词 | SCREENING COMBINATORIAL LIBRARIES PULSED ULTRAFILTRATION NONCOVALENT COMPLEXES ESTROGENIC ACTIVITY ESI-MS BINDING AFFINITY DNA INHIBITORS LIGAND |
| ISSN号 | 1005-281x |
| 通讯作者 | liu zq |
| 中文摘要 | the interaction between small drug molecule and biological target in vivo is one of the most important factors that determine the therapeutic activity of the medicine screening small drug molecule that can bind with biological target and show well pharmacological effects will promote the development of new medicine discovery significantly several approaches have been developed to screening of combinatorial libraries and natural product extracts for biologically active compounds ultrafiltration mass spectrometry is a combination of ultrafiltration equipment and mass spectrometry, which is a valuable approach for the selection, structure analysis, and identification of low molecular weight compounds that interact with biological targets in the solution phase it has been developed as a powerful tool for the determination of the interaction between small drug molecule and biological target because of its high speed, high sensitivity, and its high throughput screening ability in this paper, the fundamental principles on which the ultrafiltration mass spectrometry is based, and the experimental details that must be considered during the operation of ultrafiltration equipment are introduced the developments and applications of the ultrafiltration mass spectrometry in the studies on the interaction between small drug molecule and biological target are reviewed in addition, the development trend of the ultrafiltration mass spectrometry are also discussed |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 中文 |
| WOS记录号 | WOS:000284860900015 |
| 公开日期 | 2012-04-25 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/43262]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhou H,Song FR,Liu ZQ,et al. Applications of Ultrafiltration Mass Spectrometry in the Studies on Interaction Between Small Drug Molecule and Biological Target[J]. progress in chemistry,2010,22(11):2207-2214. |
| APA | Zhou H,Song FR,Liu ZQ,&Liu SY.(2010).Applications of Ultrafiltration Mass Spectrometry in the Studies on Interaction Between Small Drug Molecule and Biological Target.progress in chemistry,22(11),2207-2214. |
| MLA | Zhou H,et al."Applications of Ultrafiltration Mass Spectrometry in the Studies on Interaction Between Small Drug Molecule and Biological Target".progress in chemistry 22.11(2010):2207-2214. |
入库方式： OAI收割
来源：长春应用化学研究所
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