Progress of Cyclotides in Plants
文献类型：期刊论文
| 作者 | Tang Jun1,2; Tan Ninghua1 |
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2010-04-01 |
| 卷号 | 22期号:4页码:677-683 |
| 关键词 | cyclotides plants cyclic cystine knot |
| 英文摘要 | Cyclotides are a family of plant-derived macrocyclic peptides, which are formed by 28-37 amino acid residues and contain three disulfide bonds and the unique protein structural motif termed cyclic cystine knot. For their unique structures and various bioactivities, such as uterotonic, hemolytic, cytotoxic and anti-bacterial activities, and stability to resist thermal, acidic and proteolytic degradation, cyclotides can be used as a peptide-based combinational template and carrier for drug design, and attract more attentions from scientists. Now over 100 cyclotides have been isolated from about 30 species of Violaceae, Rubiaceae and Cucurbitaceae. Most contributions on cyclotides have been achieved by the research groups in Australia, Sweden and USA. Our lab is also investigating on cyclotides. This paper introduces cyclotides' research history, methods for extraction, isolation and detection, structural determination and classification, homological analysis of sequences, synthesis and biosynthesis, bioactivity and so on. |
| 学科主题 | Chemistry, Multidisciplinary |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | POLYPEPTIDE KALATA B1 ; CYCLIC CYSTINE-KNOT ; TLC CHEMICAL METHOD ; ANTI-HIV ACTIVITY ; MACROCYCLIC PEPTIDES ; CIRCULAR PROTEIN ; MOMORDICA-COCHINCHINENSIS ; CYTOTOXIC CYCLOTIDES ; OLDENLANDIA-AFFINIS ; TRYPSIN-INHIBITOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000276929300014 |
| 公开日期 | 2012-04-05 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/5180]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang Jun,Tan Ninghua. Progress of Cyclotides in Plants[J]. PROGRESS IN CHEMISTRY,2010,22(4):677-683. |
| APA | Tang Jun,&Tan Ninghua.(2010).Progress of Cyclotides in Plants.PROGRESS IN CHEMISTRY,22(4),677-683. |
| MLA | Tang Jun,et al."Progress of Cyclotides in Plants".PROGRESS IN CHEMISTRY 22.4(2010):677-683. |
入库方式： OAI收割
来源：昆明植物研究所
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