Microbial transformation of 14-deoxy-11, 12-didehydroandrographolide and 14-deoxyandrographolide and inhibitory effects on nitric oxide production of the transformation products
文献类型：期刊论文
| 作者 | Chen, Li-Xia2,3; Zhuang, Yu-Lei2,3; Shen, Lan4; Ma, En-Long5; Zhu, Hua-Jie4; Zhao, Feng1; Qiu, Feng2,3 |
| 刊名 | JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 72期号:3-4页码:248-255 |
| 关键词 | 14-Deoxy-11 14-Deoxyandrographolide Microbial transformation Cunninghamella blakesleana Nitric oxide 12-didehydroandrographolide |
| ISSN号 | 1381-1177 |
| 通讯作者 | Zhao, F (reprint author), Yantai Univ, Sch Pharm, 32 Rd QingQuan, Yantai 264005, Peoples R China |
| 英文摘要 | Microbial transformations of 14-deoxy-11, 12-didehyclroandrographolide (a) and 14-deoxyandrographolide (b) were performed by Cunninghamella blakesleana (AS 3.970), respectively. Sixteen metabolites were obtained and their structures were elucidated by spectroscopic data analyses. Among these metabolites, 3 alpha, 12S, 19-trihydroxy-8(17), 9(11)-ent-labdadien-16, 15-olide (a7), 3-oxo-8 alpha, 17 beta-epoxy-14-deoxyandrographolide (b2). 3 alpha, 17. 19-trihydroxy-8, 13-ent-labdadien-16, 15-olide (b6), and 9 beta-hydroxy-14-deoxyandrographolide (b9) are new compounds. The configuration of C-12 in metabolite a7 was determined as S by GIAO method. The proposed metabolic pathways of 14-deoxy-11, 12-didehydroandrographolide and 14-deoxyandrographolide by C blakesleana were drawn. The inhibitory effects of these compounds on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated and their preliminary structure-activity relationships (SAR) were discussed. (C) 2011 Elsevier B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Chemistry |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Physical |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | ANDROGRAPHIS-PANICULATA ; LABDANE DITERPENOIDS ; NEOANDROGRAPHOLIDE |
| 收录类别 | SCI |
| 资助信息 | Shenyang Planning Project of Science and Technology[F10-205-1-38] |
| 语种 | 英语 |
| WOS记录号 | WOS:000295299800025 |
| 公开日期 | 2012-04-10 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/5323]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Dept Nat Prod Chem, Shenyang 110016, Peoples R China 3.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China 4.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 5.Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Dept Pharmacol, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Li-Xia,Zhuang, Yu-Lei,Shen, Lan,et al. Microbial transformation of 14-deoxy-11, 12-didehydroandrographolide and 14-deoxyandrographolide and inhibitory effects on nitric oxide production of the transformation products[J]. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,2011,72(3-4):248-255. |
| APA | Chen, Li-Xia.,Zhuang, Yu-Lei.,Shen, Lan.,Ma, En-Long.,Zhu, Hua-Jie.,...&Qiu, Feng.(2011).Microbial transformation of 14-deoxy-11, 12-didehydroandrographolide and 14-deoxyandrographolide and inhibitory effects on nitric oxide production of the transformation products.JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,72(3-4),248-255. |
| MLA | Chen, Li-Xia,et al."Microbial transformation of 14-deoxy-11, 12-didehydroandrographolide and 14-deoxyandrographolide and inhibitory effects on nitric oxide production of the transformation products".JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 72.3-4(2011):248-255. |
入库方式： OAI收割
来源：昆明植物研究所
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