Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus
文献类型：期刊论文
| 作者 | Nian, Yin1,2 ; Zhang, Xian-Min2; Li, Yan2; Wang, Yuan-Yuan2; Chen, Jian-Chao2; Lu, Lu1,2; Zhou, Lin2; Qiu, Ming-Hua1
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2011-08-01 |
| 卷号 | 72期号:11-12页码:1473-1481 |
| 关键词 | Cimicifuga foetida Ranunculaceae Cycloartane triterpenoids Cytotoxicity Structure-activity relationships |
| ISSN号 | 0031-9422 |
| 通讯作者 | Qiu, MH (reprint author), Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 英文摘要 | Cycloartane triterpenoids, 2',24-O-diacetylisodahurinol-3-O-alpha-L-arabinopyranoside, 24-O-acetylisodahurinol-3-O-alpha-L-arabinopyranoside, 12 beta-hydroxy-25-anhydrocimigenol, cimigenol-12-one, 12 beta-hydroxy-15-deoxycimigenol, 2'-O-acetyl-24-epi-cimigenol-3-O-alpha-L-arabinopyranoside, 2'-O-acetylcimigenol-3-O-beta-D-xylopyranoside, 25-anhydrocimigenol-3-O-alpha-L-arabinopyranoside, 2',23-O-diacetylshenginanol-3-O-alpha-L-arabinopyranoside, and 2',24-O-diacetyl-25-anhydrohydroshengmanol-3-O-alpha-L-arabinopyranoside, together with eight known compounds, were isolated from aerial parts of Cimicifuga foetida. Their structures were determined by application of spectroscopic analyses and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, SK-BR-3, and PANC-1 cell lines indicated that three of these compounds exhibited broad-spectrum and moderate cytotoxic activities, with IC(50) values ranging from 6.20 to 22.74 mu M. By comparing previous cytotoxic testing data and bioassay results from this study, preliminary structure-activity relationships of compounds with a c imigenol-skeleton can be proposed. (C) 2011 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Plant Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 关键词[WOS] | CYCLOLANOSTANOL GLYCOSIDES ; SEQUENCE VARIATION ; SIMPLEX WORMSK ; CONSTITUENTS ; RACEMOSA ; RHIZOMES ; RANUNCULACEAE ; PHYLOGENY ; ACTAEA ; NRDNA |
| 收录类别 | SCI ; IC |
| 资助信息 | Foundation of the Key State Laboratory of Phytochemistry[P2008-ZZ05]; National Natural Science Foundation of China[30772636]; National Science Foundation of Yunnan Province[2005C0010Z] |
| 语种 | 英语 |
| WOS记录号 | WOS:000293323800019 |
| 公开日期 | 2012-04-10 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/5365]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nian, Yin,Zhang, Xian-Min,Li, Yan,et al. Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus[J]. PHYTOCHEMISTRY,2011,72(11-12):1473-1481. |
| APA | Nian, Yin.,Zhang, Xian-Min.,Li, Yan.,Wang, Yuan-Yuan.,Chen, Jian-Chao.,...&Qiu, Ming-Hua.(2011).Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus.PHYTOCHEMISTRY,72(11-12),1473-1481. |
| MLA | Nian, Yin,et al."Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus".PHYTOCHEMISTRY 72.11-12(2011):1473-1481. |
入库方式： OAI收割
来源：昆明植物研究所
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