Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity
文献类型：期刊论文
| 作者 | Zhao, Wei1,2; Pu, Jian Xin1; Du, Xue1; Wu, Ying Li3,4; Zhao, Yong1; He, Fei1; Zhang, Hai Bo1; Xue, Yong Bo1,2; Xiao, Wei Lie1; Chen, Guo Qiang3,4 |
| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 出版日期 | 2011-12-01 |
| 卷号 | 34期号:12页码:2007-2014 |
| 关键词 | Neolignan Triterpenoid Diterpenoid Isodon coetsa Cytotoxicity Human tumor cell lines |
| ISSN号 | 0253-6269 |
| 通讯作者 | Pu, JX (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China |
| 英文摘要 | Three new compounds (1-3), including a neolignan, a triterpenoid, and a diterpenoid, together with twenty known compounds (4-23), were isolated from the aerial parts of Isodon coetsa. Their structures and relative configurations were elucidated on the basis of spectroscopic data. Compounds 1, 3, 5-9, 11-13, 16-17, and 19-23 were evaluated for their cytotoxicity against HT-29, BEL-7402, and SK-OV-3 human tumor cell lines. Compound 7 showed significant inhibitory effects on all three types of cells, with IC(50) values of 2.52, 3.06, 2.14 mu M, respectively. |
| 学科主题 | Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | ENT-KAURANOIDS ; DITERPENOID CONSTITUENTS ; RABDOSIA-COETSA ; A-C ; XEROPHILUS ; RUBESCENS ; NERVOSUS |
| 收录类别 | SCI |
| 资助信息 | NSFC-Joint Foundation of Yunnan Province[U0832602]; NSFC[30830119]; Major State Basic Research Development Program of China[2009CB522300, 2009CB940900]; Science and Technology Program of Yunnan Province[2008IF010, 2008CD162] |
| 语种 | 英语 |
| WOS记录号 | WOS:000298341800003 |
| 公开日期 | 2012-04-10 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/5375]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Shanghai JiaoTong Univ Sch Med SJTU SM Coll, Chinese Minist Educ, Dept Pathophysiol, Shanghai 200025, Peoples R China 4.Shanghai JiaoTong Univ Sch Med SJTU SM Coll, Chinese Minist Educ, Key Lab Cell Differentiat & Apoptosis, Shanghai 200025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Wei,Pu, Jian Xin,Du, Xue,et al. Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity[J]. ARCHIVES OF PHARMACAL RESEARCH,2011,34(12):2007-2014. |
| APA | Zhao, Wei.,Pu, Jian Xin.,Du, Xue.,Wu, Ying Li.,Zhao, Yong.,...&Sun, Han Dong.(2011).Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity.ARCHIVES OF PHARMACAL RESEARCH,34(12),2007-2014. |
| MLA | Zhao, Wei,et al."Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity".ARCHIVES OF PHARMACAL RESEARCH 34.12(2011):2007-2014. |
入库方式： OAI收割
来源：昆明植物研究所
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