Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia
文献类型：期刊论文
| 作者 | Wu, Zhao-Yuan1,2; Li, Hai-Zhou2; Wang, Wei-Guang2; Li, Hong-Mei2; Chen, Rui3; Li, Rong-Tao1,2; Luo, Huai-Rong3
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2011-06-01 |
| 卷号 | 8期号:6页码:1182-1187 |
| 关键词 | ELLIPTICA HAND-MAZZ TRITERPENOID GLUCOSIDE LYOFOLIC ACID CONSTITUENTS |
| ISSN号 | 1612-1872 |
| 通讯作者 | Li, RT (reprint author), Kunming Univ Sci & Technol, Coll Environm Sci & Engn, Kunming 650224, Peoples R China |
| 英文摘要 | Phytochemical studies on the branches and leaves of Lyonia ovalifolia yielded a new grayanane diterpenoid, lyonin A (1), together with two known compounds, secorhodomollolides A and D (2 and 3, resp.). The structure of 1 was elucidated by combination of 1D- and 2D-NMR, and MS analyses. Compound 1 turned out to be a new, highly O-acylated grayanane diterpenoid, of which ring B has undergone an oxidative cleavage between C(9) and C(10), yielding a system differing from the previously reported grayanane type with a 5/7/6/5 ring system. Results of the cAMP regulation activity assay showed that compounds 2 and 3 at 50 mu m induced a significantly decreased cAMP level in N1E-115 neuroblastoma cells (p < 0.001), indicating neuropharmacological potential. |
| 学科主题 | Biochemistry & Molecular Biology; Chemistry |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | ELLIPTICA HAND-MAZZ ; TRITERPENOID GLUCOSIDE ; LYOFOLIC ACID ; CONSTITUENTS |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[20862011]; Fok Ying Tong Education Foundation[111040]; Program for New Century Excellent Talents on University[NCET-06-0824]; Department of Science and Technology in Yunnan Province[20080A007]; Foundation for the Author of National Excellent Doctoral Dissertation of P. R. China[200780] |
| 语种 | 英语 |
| WOS记录号 | WOS:000292200200016 |
| 公开日期 | 2012-04-10 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/5415]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Kunming Univ Sci & Technol, Coll Environm Sci & Engn, Kunming 650224, Peoples R China 2.Kunming Univ Sci & Technol, Coll Life Sci & Technol, Kunming 650224, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Zhao-Yuan,Li, Hai-Zhou,Wang, Wei-Guang,et al. Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia[J]. CHEMISTRY & BIODIVERSITY,2011,8(6):1182-1187. |
| APA | Wu, Zhao-Yuan.,Li, Hai-Zhou.,Wang, Wei-Guang.,Li, Hong-Mei.,Chen, Rui.,...&Luo, Huai-Rong.(2011).Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia.CHEMISTRY & BIODIVERSITY,8(6),1182-1187. |
| MLA | Wu, Zhao-Yuan,et al."Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia".CHEMISTRY & BIODIVERSITY 8.6(2011):1182-1187. |
入库方式： OAI收割
来源：昆明植物研究所
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