Cyclopeptide Alkaloids from Ziziphus apetala
文献类型：期刊论文
| 作者 | Han, Jing1,4; Ji, Chang-Jiu1,4; He, Wen-Jun1; Shen, Yu2,4; Leng, Ying2; Xu, Wen-Yan1; Fan, Jun-Ting1; Zeng, Guang-Zhi1; Kong, Ling-Dong3; Tan, Ning-Hua1 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2011-12-01 |
| 卷号 | 74期号:12页码:2571-2575 |
| ISSN号 | 0163-3864 |
| 通讯作者 | Tan, NH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China |
| 英文摘要 | Six novel Ia(3)-type cyclopeptide alkaloids (1-6) were isolated from stems of Ziziphus apetala. Compound 5 and the known compounds mauritine A (7) and mauritine F (8) were isolated from the roots. Their structures were determined by spectroscopic analyses and chemical methods. The total alkaloids from the roots and the isolated cyclopeptide alkaloids were tested for antidepressant behavior on mice, cytotoxicity, and 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) inhibition in vitro. Only mauritine A (7) showed inhibitory activity on 11 beta-HSD1, with IC50 values of 52.0 (human) and 31.2 mu g/mL (mouse). |
| 学科主题 | Plant Sciences; Pharmacology & Pharmacy |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 收录类别 | SCI ; IC |
| 资助信息 | National Natural Science Foundation of China[30725048, 91013002, U1032602]; National New Drug Innovation Major Project of China[2011ZX09307-002-02]; National Basic Research Program of China[2009CB522300]; Chinese Academy of Sciences[KSCX2-YW-R-177] |
| 语种 | 英语 |
| WOS记录号 | WOS:000298315800011 |
| 公开日期 | 2012-04-10 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/5465]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Jing,Ji, Chang-Jiu,He, Wen-Jun,et al. Cyclopeptide Alkaloids from Ziziphus apetala[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(12):2571-2575. |
| APA | Han, Jing.,Ji, Chang-Jiu.,He, Wen-Jun.,Shen, Yu.,Leng, Ying.,...&Tan, Ning-Hua.(2011).Cyclopeptide Alkaloids from Ziziphus apetala.JOURNAL OF NATURAL PRODUCTS,74(12),2571-2575. |
| MLA | Han, Jing,et al."Cyclopeptide Alkaloids from Ziziphus apetala".JOURNAL OF NATURAL PRODUCTS 74.12(2011):2571-2575. |
入库方式： OAI收割
来源：昆明植物研究所
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