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Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)

文献类型：期刊论文

作者Feng, Tao1; Su, Jia1; Ding, Zhi-Hui1; Zheng, Yong-Tang3,4; Li, Yan1; Leng, Ying2; Liu, Ji-Kai1
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2011-11-09
卷号59期号:21页码:11690-11695
关键词Zingiber officinale Tongling White Ginger gingerdione dimers gingerol derivatives 11 beta-HSD
ISSN号0021-8561
通讯作者Liu, JK (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
英文摘要Gingerols and their corresponding dehydration products shogaols were considered as the active principles of ginger, the rhizome of the plant Zingiber officinale, for its antioxidant, ant-inflammatory, and antitumor activities Ginger (Z. officinale) has been cultivated for thousands of years as a spice and for medicinal purposes in China. Tongling (Anhui province, China) has traditionally been regarded as an ideal cultivation place "Tongling White Ginger" enjoys a reputation for being one of the top gingers in China for its thin white peel, tender flesh, rich juice, and flavor In this study, we have isolated and identified two novel gingerdione dimers, bisgingerdiones A (1) and B (2), two new gingerol derivatives, (5R)-5-acetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one (3) and methyl (Z)-neral acetal-[6]-gingerdiol (4), and 38 known compounds (5-42) from rhizomes of Zingiber officinale collected from Tongling, China. Their structures were elucidated by means of spectroscopic methods Compounds 1-4 showed weak cytotoxic and anti-HIV-1 activities Compounds 6, 8, and 26 showed inhibitory activities against human and mouse 11 beta-HSD1 (11 beta-hydroxysteroid dehydrogenases) with IC50 values between 1 09 and 1 30 mu M.
学科主题Agriculture; Chemistry; Food Science & Technology
类目[WOS]Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]DIARYLHEPTANOIDS ; PROLIFERATION ; RHIZOMES ; CELLS
收录类别SCI ; IC
资助信息National Basic Research Program of China (973 Program)[2009CB522300]; National Natural Sciences Foundation of China[30830113]; MOST[2009ZX09501-029]
语种英语
WOS记录号WOS:000296312000041
公开日期2012-04-10
源URL[http://ir.kib.ac.cn/handle/151853/5493]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Lab Mol Immunopharmacol, Kunming 650204, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Tao,Su, Jia,Ding, Zhi-Hui,et al. Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2011,59(21):11690-11695.
APA Feng, Tao.,Su, Jia.,Ding, Zhi-Hui.,Zheng, Yong-Tang.,Li, Yan.,...&Liu, Ji-Kai.(2011).Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale).JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,59(21),11690-11695.
MLA Feng, Tao,et al."Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale)".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 59.21(2011):11690-11695.

入库方式： OAI收割

来源：昆明植物研究所

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