Synthesis and biological assay of 4-aryl-6-chloro-quinoline derivatives as novel non-nucleoside anti-HBV agents
文献类型：期刊论文
| 作者 | Guo, Rui-Hua1,2; Zhang, Quan1; Ma, Yun-Bao1; Huang, Xiao-Yan1; Luo, Jie1; Wang, Li-Jun1,2; Geng, Chang-An1,2 ; Zhang, Xue-Mei1; Zhou, Jun1; Jiang, Zhi-Yong1
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2011-02-15 |
| 卷号 | 19期号:4页码:1400-1408 |
| 关键词 | Hepatitis B virus 4-Aryl-6-chloro-quinoline Derivatives Synthesis |
| ISSN号 | 0968-0896 |
| 通讯作者 | Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China |
| 英文摘要 | A series of 4-aryl-6-chloro-quinoline derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities, namely the abilities to inhibit the secretion of HBV surface antigen (HBsAg), HBV e antigen (HBeAg), and replication of HBV DNA in HepG 2.2.15 cells. Most of the compounds exhibited moderate inhibitory activity against the secretion of HBsAg and HBeAg. Nine compounds (3, 5, 6, 7, 10, 14, 17, 20, 24) showed significant inhibition against HBV DNA replication with IC(50) values in the range of 4.4-9.8 mu M, which were comparative to that of positive control tenofovir. Of them, compounds 10, 17, and 20 had low cytotoxicities, resulting in high SI values, >551.2, >143.7, and >284.5, respectively. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | HEPATITIS-B-VIRUS ; ANTIVIRAL ACTIVITY ; IN-VITRO ; INHIBITORS ; REPLICATION ; DESIGN ; ALISOL ; POTENT |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[81025023]; Chinese Academy of Sciences[GJHI200818]; CAS-Croucher Fund[CAS-CF07/08.SC03] |
| 语种 | 英语 |
| WOS记录号 | WOS:000287592100004 |
| 公开日期 | 2012-04-10 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/5521]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Rui-Hua,Zhang, Quan,Ma, Yun-Bao,et al. Synthesis and biological assay of 4-aryl-6-chloro-quinoline derivatives as novel non-nucleoside anti-HBV agents[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(4):1400-1408. |
| APA | Guo, Rui-Hua.,Zhang, Quan.,Ma, Yun-Bao.,Huang, Xiao-Yan.,Luo, Jie.,...&Chen, Ji-Jun.(2011).Synthesis and biological assay of 4-aryl-6-chloro-quinoline derivatives as novel non-nucleoside anti-HBV agents.BIOORGANIC & MEDICINAL CHEMISTRY,19(4),1400-1408. |
| MLA | Guo, Rui-Hua,et al."Synthesis and biological assay of 4-aryl-6-chloro-quinoline derivatives as novel non-nucleoside anti-HBV agents".BIOORGANIC & MEDICINAL CHEMISTRY 19.4(2011):1400-1408. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。