Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives
文献类型：期刊论文
| 作者 | Bai, Bing1,3; Li, Xing-Yao1,3; Li, Yan1 ; Zhu, Hua-Jie1,2
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2011-04-15 |
| 卷号 | 21期号:8页码:2302-2304 |
| 关键词 | beta-Amino alcohol Cytotoxic activity Structure-activity relationship MTT |
| ISSN号 | 0960-894X |
| 通讯作者 | Li, Y (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Organ Synth & Nat Prod Lab, Kunming 650204, Peoples R China |
| 英文摘要 | Three series of novel beta-amino alcohols possessing an N-anthranyl group have been obtained using tryptophan as the major starting material. These compounds were screened for cytotoxic activity against five human cancer cell lines in vitro by MTT assay, and some of them exhibited potential ability to be anticancer agents. Structure-activity relationship was carefully investigated. Only the compounds possessing small substituents (H or CH(3)) at C-6 position showed the same activity as cisplatin (DDP) did. (C) 2011 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Chemistry |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | LIGANDS ; DIETHYLZINC ; ABRINE ; ENANTIOSELECTIVITY ; BENZALDEHYDE ; COLCHICINE ; ALDEHYDES ; TUBULIN ; AGENTS |
| 收录类别 | SCI |
| 资助信息 | NSFC[30873141]; 973 Program[2009CB522300]; program of recruited science and technology talents[2009C1120]; State Key Laboratory of Phytochemistry and Plant Resources in West China; Hebei University |
| 语种 | 英语 |
| WOS记录号 | WOS:000289074700025 |
| 公开日期 | 2012-04-10 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/5523]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Organ Synth & Nat Prod Lab, Kunming 650204, Peoples R China 2.Hebei Univ, Minist Educ, Key Lab Med Chem & Mol Diag, Coll Life Sci, Baoding 071002, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Bing,Li, Xing-Yao,Li, Yan,et al. Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(8):2302-2304. |
| APA | Bai, Bing,Li, Xing-Yao,Li, Yan,&Zhu, Hua-Jie.(2011).Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(8),2302-2304. |
| MLA | Bai, Bing,et al."Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.8(2011):2302-2304. |
入库方式： OAI收割
来源：昆明植物研究所
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