Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro
文献类型：期刊论文
| 作者 | Pei, Ying1; Chen, Zhen-Ping1; Ju, Huai-Qiang1; Komatsu, Masaaki2; Ji, Yu-hua3; Liu, Ge4; Guo, Chao-wan4; Zhang, Ying-Jun5 ; Yang, Chong-Ren5; Wang, Yi-Fei1
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| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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| 出版日期 | 2011-02-11 |
| 卷号 | 405期号:2页码:186-191 |
| 关键词 | Autophagy Pentagalloylglucose (PGG) HSV-1 infections Anti-viral activity |
| ISSN号 | 0006-291X |
| 通讯作者 | Wang, YF (reprint author), Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China |
| 英文摘要 | Pentagalloylglucose (PGG) is a natural polyphenolic compound with broad-spectrum anti-viral activity, however, the mechanisms underlying anti-viral activity remain undefined. In this study, we investigated the effects of PGG on anti-viral activity against Herpes simplex virus type 1 (HSV-1) associated with autophagy. We found that the PGG anti-HSV-1 activity was impaired significantly in MEF-atg7(-/-) cells (autophagy-defective cells) derived from an atg7(-/-) knockout mouse. Transmission electron microscopy revealed that PGG-induced autophagosomes engulfed HSV-1 virions. The mTOR signaling pathway, an essential pathway for the regulation of autophagy, was found to be suppressed following PGG treatment. Data presented in this report demonstrated for the first time that autophagy induced following PGG treatment contributed to its anti-HSV activity in vitro. (C) 2011 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | SIGNALING PATHWAY ; MAMMALIAN TARGET ; CELLS ; PROTEIN ; KINASE ; 1,2,3,4,6-PENTA-O-GALLOYL-BETA-D-GLUCOSE ; INHIBITION ; EXPRESSION ; COMPLEX ; CANCER |
| 收录类别 | SCI |
| 资助信息 | National Science Foundation of China[U0632010]; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences[P2008-KF07, P2008-ZZ08]; Ministry of Education (MOE)[211]; Fundamental Research Funds for the Central Universities; Tokyo Biochemical Research Foundation; Ministry of Education, Culture, Sports, Science and Technology of Japan[22590274] |
| 语种 | 英语 |
| WOS记录号 | WOS:000287627500007 |
| 公开日期 | 2012-04-10 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/5569]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China 2.Tokyo Metropolitan Inst Med Sci, Lab Frontier Sci, Bunkyo Ku, Tokyo 1138613, Japan 3.Jinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R China 4.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Div Mol Pharmacol Infect Agents, Nagasaki 8528521, Japan 5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pei, Ying,Chen, Zhen-Ping,Ju, Huai-Qiang,et al. Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,405(2):186-191. |
| APA | Pei, Ying.,Chen, Zhen-Ping.,Ju, Huai-Qiang.,Komatsu, Masaaki.,Ji, Yu-hua.,...&Kitazato, Kaio.(2011).Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,405(2),186-191. |
| MLA | Pei, Ying,et al."Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 405.2(2011):186-191. |
入库方式： OAI收割
来源：昆明植物研究所
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