Biodistribution and toxicity of nanodiamonds in mice after intratracheal instillation
文献类型：期刊论文
| 作者 | Zhang, XY ; Yin, JL ; Kang, C ; Li, J ; Zhu, Y ; Li, WX ; Huang, Q ; Zhu, ZY |
| 刊名 | TOXICOLOGY LETTERS
 |
| 出版日期 | 2010 |
| 卷号 | 198期号:2页码:7 |
| 关键词 | Nanodiamonds Biodistribution Micro-SPECT Intratracheal instillation Toxicity |
| ISSN号 | 0378-4274 |
| 通讯作者 | Li, WX (reprint author), Chinese Acad Sci, Phys Biol Lab, Shanghai Inst Appl Phys, 2019 Jialuo Rd, Shanghai 201800, Peoples R China |
| 英文摘要 | Nanodiamonds (NDs) are receiving increasing attention in materials science and nanotechnology-based industries for a large variety of applications, including protein immobilization, biosensors, therapeutic molecule delivery, and bioimaging. However, limited information is known about their biokinetic behavior and toxicity in vivo. In this article, we investigated the biodistribution of NDs using radiotracer techniques and evaluated its acute toxicity in Kun Ming mice after intratracheal instillation. The biodistribution showed that, besides having the highest retention in the lung, NDs were distributed mainly in the spleen, liver, bone and heart. An analysis of histological morphology and biochemical parameters indicated that NDs could induce dose-dependent toxicity to the lung, liver, kidney and blood. This work provided fundamental data for understanding the biodistribution of NDs and will provide guidance for further study of their toxicity. Crown Copyright (C) 2010 Published by Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Toxicology |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281942800020 |
| 公开日期 | 2012-04-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/6854]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Zhang, XY,Yin, JL,Kang, C,et al. Biodistribution and toxicity of nanodiamonds in mice after intratracheal instillation[J]. TOXICOLOGY LETTERS,2010,198(2):7. |
| APA | Zhang, XY.,Yin, JL.,Kang, C.,Li, J.,Zhu, Y.,...&Zhu, ZY.(2010).Biodistribution and toxicity of nanodiamonds in mice after intratracheal instillation.TOXICOLOGY LETTERS,198(2),7. |
| MLA | Zhang, XY,et al."Biodistribution and toxicity of nanodiamonds in mice after intratracheal instillation".TOXICOLOGY LETTERS 198.2(2010):7. |
入库方式： OAI收割
来源：上海应用物理研究所
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