Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine
文献类型：期刊论文
| 作者 | Nimgirawath, Surachai1; Lorpitthaya, Rujee1; Wanbanjob, Asawin1; Taechowisan, Thongchai2; Shen, Yue-Mao3 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2009 |
| 卷号 | 14期号:1页码:89-101 |
| 关键词 | Alkaloid Anti-inflammatory Activity Aporphine Isoquinoline Synthesis Radical Cyclization |
| ISSN号 | 1420-3049 |
| 通讯作者 | surachai@su.ac.th ; G050010@ntu.edu.sg ; winsusc@gmail.com ; tthongch@su.ac ; yshen@mail.kib.ac.cn |
| 英文摘要 | The structure previously assigned to the phenolic noraporphine alkaloid, (-)-norannuradhapurine has been confirmed by a total synthesis of the racemic alkaloid in which the key step involved the formation of the C ring by a radical-initiated cyclization. although inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028, (+/-)-norannuradhapurine inhibits the production of NO, PGE(2), TNF-alpha, IL-1 beta and IL-6 and the expression of iNOS and COX-2 in RAW 264.7 macrophages stimulated with LPS in vitro. |
| 学科主题 | Chemistry, Organic |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | APORPHINES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000262791200009 |
| 公开日期 | 2012-04-18 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/5591]  |
| 专题 | 昆明植物研究所_离退休 |
| 作者单位 | 1.Silpakorn Univ, Fac Sci, Dept Chem, Nakhon Pathom 73000, Thailand 2.Silpakorn Univ, Fac Sci, Dept Microbiol, Nakhon Pathom 73000, Thailand 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nimgirawath, Surachai,Lorpitthaya, Rujee,Wanbanjob, Asawin,et al. Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine[J]. MOLECULES,2009,14(1):89-101. |
| APA | Nimgirawath, Surachai,Lorpitthaya, Rujee,Wanbanjob, Asawin,Taechowisan, Thongchai,&Shen, Yue-Mao.(2009).Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine.MOLECULES,14(1),89-101. |
| MLA | Nimgirawath, Surachai,et al."Total Synthesis and the Biological Activities of (+/-)-Norannuradhapurine".MOLECULES 14.1(2009):89-101. |
入库方式： OAI收割
来源：昆明植物研究所
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