Plugging into Proteins: Poisoning Protein Function by a Hydrophobic Nanoparticle
文献类型：期刊论文
| 作者 | Zuo, GH ; Huang, Q ; Wei, GH ; Zhou, RH ; Fang, HP |
| 刊名 | ACS NANO
 |
| 出版日期 | 2010 |
| 卷号 | 4期号:12页码:7 |
| 关键词 | nanoparticle toxicity protein-nanoparticle interaction protein function poisoning hydrophobic interaction molecular dynamics |
| ISSN号 | 1936-0851 |
| 通讯作者 | Zhou, RH (reprint author), IBM Corp, Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA |
| 英文摘要 | Nanoscale particles have become promising materials In many fields, such as cancer therapeutics, diagnosis, Imaging, drug delivery, catalysis, as well as biosensors. In order to stimulate and facilitate these applications, there is an urgent need for the understanding of the nanoparticle toxicity and other risks involved with these nanoparticles to human health. In this study, we use large-scale molecular dynamics simulations to study the interaction between several proteins (WW domains) and carbon nanotubes (one form of hydrophobic nanopartides). We have found that the carbon nanotube can plug into the hydrophobic core of proteins to form stable complexes. This plugging of nanotubes disrupts and blocks the active sites of WW domains from binding to the corresponding ligands, thus leading to the loss of the original function of the proteins. The key to this observation is the hydrophobic Interaction between the nanoparticle and the hydrophobic residues, particularly tryptophans, in the core of the domain. We believe that these findings might provide a novel route to the nanopartide toxicity on the molecular level for the hydrophobic nanopartides. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000285449100058 |
| 公开日期 | 2012-04-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/7010]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Zuo, GH,Huang, Q,Wei, GH,et al. Plugging into Proteins: Poisoning Protein Function by a Hydrophobic Nanoparticle[J]. ACS NANO,2010,4(12):7. |
| APA | Zuo, GH,Huang, Q,Wei, GH,Zhou, RH,&Fang, HP.(2010).Plugging into Proteins: Poisoning Protein Function by a Hydrophobic Nanoparticle.ACS NANO,4(12),7. |
| MLA | Zuo, GH,et al."Plugging into Proteins: Poisoning Protein Function by a Hydrophobic Nanoparticle".ACS NANO 4.12(2010):7. |
入库方式： OAI收割
来源：上海应用物理研究所
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