Preparation of novel bilayer hydrogels by combination of irradiation and freeze-thawing and their physical and biological properties
文献类型：期刊论文
| 作者 | Yang, XM ; Yang, K ; Yu, F ; Chen, XL ; Wu, SW（吴胜伟） ; Zhu, ZY(朱智勇） |
| 刊名 | POLYMER INTERNATIONAL
 |
| 出版日期 | 2009 |
| 卷号 | 58期号:11页码:8 |
| 关键词 | bilayer hydrogel combination of irradiation and freeze-thawing water-soluble chitosan MTT assay biocompatibility |
| ISSN号 | 0959-8103 |
| 通讯作者 | Zhu, ZY (reprint author), Chinese Acad Sci, Dept Nucl Anal Tech, Shanghai Inst Appl Phys, POB 800-204, Shanghai 201800, Peoples R China |
| 英文摘要 | BACKGROUND: Hydrogels made by irradiation or freeze-thawing often exhibit poor mechanical strength; therefore we investigated a novel synthetic method to circumvent this detrimental effect. We report a series of novel bilayer poly(vinyl alcohol) (PVA)/water-soluble chitosan (ws-chitosan)/glycerol hydrogels prepared by a combination of irradiation and freeze-thawing. Scanning electron microscopy morphology, swelling behavior, mechanical strength, elongation at break, PVA dissolution behavior and bovine serum albumin (BSA) release profile of the bilayer hydrogels were compared with those of hydrogels made by irradiation and freeze-thawing followed by irradiation. The cytotoxicity of the bilayer hydrogels was studied using a tetrazolium salt (MTT) assay. RESULTS: The novel bilayer hydrogels contain one layer made by freeze-thawing followed by irradiation and the other layer made by irradiation. The preparation method provides the two layers with good combination force in the wet state. However, the two layers are not combined very well in the freeze-dried state due to the difference in microstructure. The bilayer hydrogels have large swelling capacity and good mechanical strength, and these properties can be varied by changing freeze-thawing cycles, irradiation doses and the relative thickness of the two layers. The PVA and BSA release behaviors show that the bilayer hydrogels have a small amount of dissolved PVA and can prolong the BSA release time. The MTT assay shows that extracts of the bilayer hydrogels are non-toxic towards L929 mouse fibroblasts. CONCLUSION: The novel bilayer hydrogels prepared in this study show good physical properties with no cytotoxicity, indicating that they are suitable for biomedical applications, such as in wound dressings and drug delivery devices. (C) 2009 Society of Chemical Industry |
| 学科主题 | Polymer Science |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271515700010 |
| 公开日期 | 2012-04-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/7018]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Yang, XM,Yang, K,Yu, F,et al. Preparation of novel bilayer hydrogels by combination of irradiation and freeze-thawing and their physical and biological properties[J]. POLYMER INTERNATIONAL,2009,58(11):8. |
| APA | Yang, XM,Yang, K,Yu, F,Chen, XL,Wu, SW,&Zhu, ZY.(2009).Preparation of novel bilayer hydrogels by combination of irradiation and freeze-thawing and their physical and biological properties.POLYMER INTERNATIONAL,58(11),8. |
| MLA | Yang, XM,et al."Preparation of novel bilayer hydrogels by combination of irradiation and freeze-thawing and their physical and biological properties".POLYMER INTERNATIONAL 58.11(2009):8. |
入库方式： OAI收割
来源：上海应用物理研究所
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