Protective effects of silybin and analogues against X-ray radiation-induced damage
文献类型：期刊论文
| 作者 | Fu, HY ; Lin, MZ ; Katsumura, Y ; Yokoya, A ; Hata, K ; Muroya, Y ; Fujii, K ; Shikazono, N |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2010 |
| 卷号 | 42期号:7页码:7 |
| 关键词 | silybin DNA free radicals antioxidant protection |
| ISSN号 | 1672-9145 |
| 通讯作者 | Fu, HY (reprint author), Chinese Acad Sci, Lab Radiat Chem & Technol, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| 英文摘要 | Silybin (SLB) and similar analogues, namely, hesperetin (HESP), naringenin (NAN) and naringin (NAR), are believed to be active constituents of natural flavonoids that have been reported as chemopreventive agents for certain cancers. Moreover, SLB and analogues have been determined to fast repair DNA bases from oxidative damage by pulse radiolysis techniques. The present study was designed to evaluate the protective effects of SLB and analogues on soft X-ray-induced damage to plasmid DNA in vitro. The DNA damage was determined by agarose gel electrophoresis. SLB and analogues were found to protect DNA from radiation damage at micromolar concentrations. Among the compounds tested, HESP and SLB were the most effective in preventing X-ray-induced formation of DNA single-strand breaks (SSB). A comparison of these results with other experiments showed that the ability of SLB and analogues to inhibit DNA damage in vitro correlated with the ability of the compounds to scavenge free radicals. Our work revealed that natural flavonoids, SLB and analogues may be used as potent radioprotectors against radiation damage. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000279475200008 |
| 公开日期 | 2012-04-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/7025]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Fu, HY,Lin, MZ,Katsumura, Y,et al. Protective effects of silybin and analogues against X-ray radiation-induced damage[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2010,42(7):7. |
| APA | Fu, HY.,Lin, MZ.,Katsumura, Y.,Yokoya, A.,Hata, K.,...&Shikazono, N.(2010).Protective effects of silybin and analogues against X-ray radiation-induced damage.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,42(7),7. |
| MLA | Fu, HY,et al."Protective effects of silybin and analogues against X-ray radiation-induced damage".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 42.7(2010):7. |
入库方式： OAI收割
来源：上海应用物理研究所
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