Radial compression property of ds-DNA molecules studied by a mesoscale model
文献类型：期刊论文
| 作者 | Lei, XL（雷晓玲） ; Hu, J（胡钧） ; Fang, HP（方海平） |
| 刊名 | EPL
 |
| 出版日期 | 2010 |
| 卷号 | 89期号:4页码:6 |
| ISSN号 | 0295-5075 |
| 通讯作者 | Lei, XL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, POB 800-204, Shanghai 201800, Peoples R China |
| 英文摘要 | The elastic properties of double-stranded DNA (ds-DNA) molecules are believed to play an important role in their biological functions. By using a mesoscale model, we construct a simple cylinder-DNA-surface system to explore the radial elastic property of a ds-DNA molecule through a Langevin-dynamics-based computer simulation. The numerical predictions of the radial elastic property are favorable with the recent experimental results. The analysis of the hydrogen bonds and base stacking interaction shows that local conformation transition occurs through the breaking of local hydrogen bonds, and this transition minimizes the inner strain aggregated during compression. This behavior provides an alternative method for studying the local property of ds-DNA, which is expected to be helpful in better understanding the local interaction between ds-DNA and protein, and the mechanics of the short-segment DNA molecule. Copyright (C) EPLA, 2010 |
| 学科主题 | Physics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000276100300034 |
| 公开日期 | 2012-04-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/7029]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Lei, XL,Hu, J,Fang, HP. Radial compression property of ds-DNA molecules studied by a mesoscale model[J]. EPL,2010,89(4):6. |
| APA | Lei, XL,Hu, J,&Fang, HP.(2010).Radial compression property of ds-DNA molecules studied by a mesoscale model.EPL,89(4),6. |
| MLA | Lei, XL,et al."Radial compression property of ds-DNA molecules studied by a mesoscale model".EPL 89.4(2010):6. |
入库方式： OAI收割
来源：上海应用物理研究所
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