Superparamagnetic magnetite nanocrystal clusters: a sensitive tool for MR cellular imaging
文献类型：期刊论文
| 作者 | Xu, FH（许凤华） ; Cheng, CM ; Xu, FJ ; Zhang, CF ; Xu, H ; Xie, X ; Yin, DZ(尹端沚） ; Gu, HC |
| 刊名 | NANOTECHNOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 20期号:40页码:10 |
| ISSN号 | 0957-4484 |
| 通讯作者 | Zhang, CF (reprint author), Shanghai Jiao Tong Univ, Med X Res Inst, Shanghai 200030, Peoples R China |
| 英文摘要 | Silica coated, PEI and citric acid hybrid superparamagnetic magnetite nanocrystal clusters (SMNC) were synthesized using either a mini-emulsion/sol-gel method or a polyol technique. After careful characterization of the size, structure, composition, and magnetic properties, the as-synthesized SMNC were used for cell labeling while the MR detection sensitivity of cells labeled with silica SMNC was performed with a 3 T whole body MR scanner. TEM investigations revealed that the sizes of the SMNC were about 200 nm and the SMNC mainly consisted of magnetite nanoparticles imbedded in a PEI, citric acid or polystyrene scaffold. Silica and citric acid SMNC were highly negatively charged and PEI SMNC were positively charged. Relaxometry measurements revealed that these SMNC possessed a very high MR sensitivity (silica SMNC: r(2) = 299 s(-1) mM(-1), PEI SMNC: r(2) = 124 s(-1) mM(-1)), especially for the citric acid SMNC (r(2) = 360 s(-1) mM(-1)). Furthermore, when used for cell (RAW264.7 cells) labeling, the SMNC had no adverse effect on cell viability, and the cell uptake of the SMNC show a dose-and time-dependent feature. MR imaging of cells labeled with silica SMNC indicated that cells with a concentration as low as 10 x 10(3) cells ml(-1) could be detected with a 3 T MRI scanner. Our study demonstrated that superparamagnetic magnetite nanocrystal clusters are a sensitive tool for cell imaging. |
| 学科主题 | Science & Technology - Other Topics; Materials Science; Physics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000269929900002 |
| 公开日期 | 2012-04-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/7069]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Xu, FH,Cheng, CM,Xu, FJ,et al. Superparamagnetic magnetite nanocrystal clusters: a sensitive tool for MR cellular imaging[J]. NANOTECHNOLOGY,2009,20(40):10. |
| APA | Xu, FH.,Cheng, CM.,Xu, FJ.,Zhang, CF.,Xu, H.,...&Gu, HC.(2009).Superparamagnetic magnetite nanocrystal clusters: a sensitive tool for MR cellular imaging.NANOTECHNOLOGY,20(40),10. |
| MLA | Xu, FH,et al."Superparamagnetic magnetite nanocrystal clusters: a sensitive tool for MR cellular imaging".NANOTECHNOLOGY 20.40(2009):10. |
入库方式： OAI收割
来源：上海应用物理研究所
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