Transient species of several fluoroquinolones and their reactions with amino acids
文献类型：期刊论文
| 作者 | Zhang, P ; Song, XY ; Li, HX ; Yao, SD ; Wang, WF |
| 刊名 | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
 |
| 出版日期 | 2010 |
| 卷号 | 215期号:40577页码:5 |
| 关键词 | Fluoroquinolone Laser flash photolysis Pulse radiolysis Photochemistry Amino acid |
| ISSN号 | 1010-6030 |
| 通讯作者 | Wang, WF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| 英文摘要 | The photochemistry of several fluoroquinolone antibiotics (FQs). including enoxacin (ENX), norfloxacin (NFX). and ciprofloxacin (CPX), have been investigated in neutral aqueous solution by laser flash photolysis and pulse radiolysis Transient absorption spectra of FQs were observed and transient species were assigned The absorption maxima (lambda(max)) of triplet states of ENX. NFX and CPX were located at 520 nm, X 620 nm and 610 nm, respectively. The radical anions of FQs were characterized by lambda(max) = 370 nm Reactions of the FQ triplet states with amino acids (tyrosine [TyrOH]. tryptophan [TipH], glycine [Gly] and cysteine [CyS]) were investigated in different conditions. All three FQ triplet states can oxidize TrpH and TyrOH. The FQ radical anions and oxidized radicals of TrpH (Trp(center dot)) and TyrOH (TyrO(center dot)) were directly observed. Under aerobic conditions, the photooxidation of TrpH and TyrOH involves both Type I and Type II mechanisms. There were no distinct quenching reactions of the FQ triplet states by Gly and Cys in N(2)-saturated aqueous solutions (C) 2010 Elsevier B.V All rights reserved. |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000283630200009 |
| 公开日期 | 2012-04-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/7103]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Zhang, P,Song, XY,Li, HX,et al. Transient species of several fluoroquinolones and their reactions with amino acids[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,2010,215(40577):5. |
| APA | Zhang, P,Song, XY,Li, HX,Yao, SD,&Wang, WF.(2010).Transient species of several fluoroquinolones and their reactions with amino acids.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,215(40577),5. |
| MLA | Zhang, P,et al."Transient species of several fluoroquinolones and their reactions with amino acids".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY 215.40577(2010):5. |
入库方式： OAI收割
来源：上海应用物理研究所
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