Application of X-ray Phase Contrast Imaging Technique in Detection of Pulmonary Lesions Induced by Multi-Walled Carbon Nanotubes in Rats
文献类型：期刊论文
| 作者 | Li, JG ; Xue, YL(薛艳玲） ; Han, B ; Li, QN（李晴暖） ; Liu, LX ; Xiao, TQ（肖体乔） ; Li, WX（李文新） |
| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
 |
| 出版日期 | 2008 |
| 卷号 | 8期号:7页码:3357 |
| ISSN号 | 1533-4880 |
| 通讯作者 | Xiao, TQ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| 英文摘要 | With X-ray phase contrast imaging technique, the pulmonary lesions induced by multi-walled carbon nanotubes were preliminarily studied in this work. After 0.1, 1 and 2 mg nanotubes were delivered into lungs of rats via trachea, their acute pulmonary toxicity (at 5-day postexposure) was assessed using X-ray phase contrast, absorption contrast imaging and routine pathological slice techniques. As such, the long-term pulmonary toxicity (at 140-day postexposure), induced by single intratracheal instillation of 0.1 mg nanotubes, was assessed using X-ray phase contrast imaging and pathological slice techniques. As a consequence, the nanotubes could induce obvious density and structural integrity alternation in lung tissue at 5-day postexposure and granulomas at 140-day postexposure, and these pathologic lesions could be efficiently detected out with the phase imaging technique. By comparison, this technique not only gained advantage over the conventional X-ray absorption contrast imaging but also could supply the gap of routine pathological slice in detecting pulmonary lesions induced by carbon nanotubes. It is hoped that this work can act as an impetus for further application of phase imaging technique to nanotoxicology and to assessment of occupational safety of nanomaterials. |
| 学科主题 | Science & Technology - Other Topics; Materials Science; Physics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260776600008 |
| 公开日期 | 2012-04-18 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/7655]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Li, JG,Xue, YL,Han, B,et al. Application of X-ray Phase Contrast Imaging Technique in Detection of Pulmonary Lesions Induced by Multi-Walled Carbon Nanotubes in Rats[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2008,8(7):3357. |
| APA | Li, JG.,Xue, YL.,Han, B.,Li, QN.,Liu, LX.,...&Li, WX.(2008).Application of X-ray Phase Contrast Imaging Technique in Detection of Pulmonary Lesions Induced by Multi-Walled Carbon Nanotubes in Rats.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,8(7),3357. |
| MLA | Li, JG,et al."Application of X-ray Phase Contrast Imaging Technique in Detection of Pulmonary Lesions Induced by Multi-Walled Carbon Nanotubes in Rats".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 8.7(2008):3357. |
入库方式： OAI收割
来源：上海应用物理研究所
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