Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation
文献类型：期刊论文
| 作者 | Xu, JY ; Li, QN(李晴暖） ; Li, JG ; Ran, TC ; Wu, SW（吴胜伟） ; Song, WM ; Chen, SL ; Li, WX(李文新） |
| 刊名 | CARBON
 |
| 出版日期 | 2007 |
| 卷号 | 45期号:9页码:1865 |
| ISSN号 | 0008-6223 |
| 通讯作者 | Li, WX (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| 英文摘要 | An increasing number of studies have been devoted to studying the respiratory toxicity of carbon nanomaterials, but little information is known, thus far, on the biodistribution of these nanomaterials after inhalation or intratracheal instillation. We synthesized and labeled a polyhydroxylated derivative of fullerene C-60(OH)(x) (x = 22,24) with Tc-99m. With single photon emission computed tomography imaging and (gamma)-ray counting techniques, the biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation was studied. It was found that, besides the highest retention in the lung, Tc-99m-C-67(OH)(x) is distributed mainly in the liver, bone, and spleen, with no uptake found in brain. The long-term retention in the lung and the very fast clearance from the blood revealed a transient characteristic of penetrating the alveolar-capillary barrier. The dimensions and size distribution, as well as in vivo aggregation of 99mTc-C60(OH)(x),, may affect the capability and kinetic process of penetrating the alveolar-capillary barrier. The results provide guidance for further study of the respiratory toxicity of carbon nanornaterials. (c) 2007 Elsevier Ltd. All rights reserved. |
| 学科主题 | Physics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248935500018 |
| 公开日期 | 2012-04-18 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/7664]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Xu, JY,Li, QN,Li, JG,et al. Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation[J]. CARBON,2007,45(9):1865. |
| APA | Xu, JY.,Li, QN.,Li, JG.,Ran, TC.,Wu, SW.,...&Li, WX.(2007).Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation.CARBON,45(9),1865. |
| MLA | Xu, JY,et al."Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation".CARBON 45.9(2007):1865. |
入库方式： OAI收割
来源：上海应用物理研究所
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