Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation
文献类型：期刊论文
| 作者 | Li, JG ; Li, WX(李文新） ; Xu, JY ; Cai, XQ ; Liu, RL（刘瑞丽） ; Li, YJ（李永军） ; Zhao, QF ; Li, QN（李晴暖） |
| 刊名 | ENVIRONMENTAL TOXICOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 22期号:4页码:415 |
| ISSN号 | 1520-4081 |
| 通讯作者 | Li, QN (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| 英文摘要 | The pathological lesions induced by multiwalled carbon nanotubes (MWCNTs) in bronchi and alveoli of mice were studied by intratracheal instillation and inhalation. In instillation groups, the dose was 0.05 mg MWCNTs/mouse. Similar size clumps of MWCNTs were distributed in bronchi and alveoli. The clumps led to inflammation to the lining wall of bronchi and severe destruction to alveolar netted structure around them. In the inhalation groups, the mice were exposed to aerosolized MWCNTs with mean concentration of 32.61 mg/m(3), the intralung deposition dose were roughly 0.07, 0.14, and 0.21 mg in the 8-day group, 16-day group, and 24-day group, respectively. Most of aggregations of MWCNTs in the alveoli were smaller than that in bronchi. The aggregations induced proliferation and thickening of alveolar walls. With the exception of these moderate pathological lesions, the general alveolar structure was still remained. The preliminary study demonstrated a difference in lung pathological lesions induced by instilled MWCNTs and inhaled ones, which may be due to the different size and distribution of aggregations of MWCNTs in lung. (C) 2007 Wiley Periodicals, Inc. Environ Toxicol 22: 415-421, 2007. |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248189800009 |
| 公开日期 | 2012-04-18 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/7675]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Li, JG,Li, WX,Xu, JY,et al. Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation[J]. ENVIRONMENTAL TOXICOLOGY,2007,22(4):415. |
| APA | Li, JG.,Li, WX.,Xu, JY.,Cai, XQ.,Liu, RL.,...&Li, QN.(2007).Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation.ENVIRONMENTAL TOXICOLOGY,22(4),415. |
| MLA | Li, JG,et al."Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation".ENVIRONMENTAL TOXICOLOGY 22.4(2007):415. |
入库方式： OAI收割
来源：上海应用物理研究所
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