Fast repair of oxidative DNA damage by phenylpropanoid glycosides and their analogues
文献类型：期刊论文
| 作者 | Shi, YM ; Wang, WF(王文锋） ; Huang, CY ; Jia, ZJ ; Yao, SD（姚思德） ; Zheng, RL |
| 刊名 | MUTAGENESIS
 |
| 出版日期 | 2008 |
| 卷号 | 23期号:1页码:19 |
| ISSN号 | 0267-8357 |
| 通讯作者 | Zheng, RL (reprint author), Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China |
| 英文摘要 | The repair activities and reaction mechanisms of phenylpropanoid glycosides (PPGs) and their analogues, isolated from Chinese folk medicinal herbs, towards oxidative DNA damage were studied with pulse radiolytic technique. On pulse irradiation of nitrogen-saturated 4 mM poly C aqueous solution containing one of the tested polyphenols, 40 mM K2S2O8 and 200 mM t-BuOH, the transient absorption spectrum of the oxidative radical of poly C decays with the concurrent formation of the phenoxyl radical of the tested polyphenols within several tens of microseconds after the electron pulse irradiation. The result indicated that there was a repair reaction between oxidative radical of poly C and the tested polyphenols. The repair activities also were observed for the tested polyphenols towards the radical cations of single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). The rate constants were determined to be 3.7-6.4 x 10(9), 4.8-5.5 x 10(8) and 8.8-10.3 x 10(8) M-1.sec(-1) for the repair reactions of oxidative radical of poly C and radical cations of ssDNA and dsDNA, respectively. The result of this study together with those of our previous studies demonstrates that PPGs and their analogues can fast repair not only the damage of deoxynucleoside and deoxynucleotide but also the damage of integral DNA, with the latter being closer to a cellular condition. |
| 学科主题 | Physics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000252718200002 |
| 公开日期 | 2012-04-18 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/7729]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Shi, YM,Wang, WF,Huang, CY,et al. Fast repair of oxidative DNA damage by phenylpropanoid glycosides and their analogues[J]. MUTAGENESIS,2008,23(1):19. |
| APA | Shi, YM,Wang, WF,Huang, CY,Jia, ZJ,Yao, SD,&Zheng, RL.(2008).Fast repair of oxidative DNA damage by phenylpropanoid glycosides and their analogues.MUTAGENESIS,23(1),19. |
| MLA | Shi, YM,et al."Fast repair of oxidative DNA damage by phenylpropanoid glycosides and their analogues".MUTAGENESIS 23.1(2008):19. |
入库方式： OAI收割
来源：上海应用物理研究所
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