Feasibility of (99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas
文献类型：期刊论文
| 作者 | Zhao, J ; Qi, YJ(漆玉金） ; Dai, QS（代秋声） ; Zhang, XZ ; Qu, XM ; Huang, J ; Liu, XD |
| 刊名 | NUCLEAR SCIENCE AND TECHNIQUES
 |
| 出版日期 | 2008 |
| 卷号 | 19期号:2页码:105 |
| ISSN号 | 1001-8042 |
| 通讯作者 | Liu, XD (reprint author), Fudan Univ, Huashan Hosp, Dept Nucl Med, Shanghai 200040, Peoples R China |
| 英文摘要 | In this paper, (99m)Tc-TRODAT-1 Micro-SPECT (single-photon emission computed tomography) was used for imaging dopamine transporter (DAT) in retinas and to investigate the changes of DAT in retinas of pigs with form deprivation myopia. Pigmented guinea pigs aged 3 weeks were devided into form deprivation myopia (FDM) group (n=6) and normal control group (n=6). The test group wore translucent goggles randomly for 4 weeks, and both groups underwent biometric measurement (refraction and axial length) before and after the experiment. Micro-SPECT retinas imaging was performed at the 4(th) week after injection of (99m)Tc-TRODAT-1. The retinas were clearly resolved in the images. The ratio of (99m)Tc-TRODAT-1 uptake in the myopic retinas (11.55 +/- 2.80) was 3.64 +/- 1.40 lower than that in the control eye (15.20 +/- 1.98), and 2.35 +/- 1.05 lower than that in the fellow eyes (13.90 +/- 2.04). The results showed that (99m)Tc-TRODAT-1 Micro-SPECT eye imaging can be used to trace the distribution and changes of DAT in retina, and DAT in the myopic retinas were lower than that in the normal control eyes and fellow eyes. Micro-SPECT may provide a new approach for further studies on the role of dopamine system in the experimental myopia. |
| 学科主题 | Physics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000256955100009 |
| 公开日期 | 2012-04-18 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/7730]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Zhao, J,Qi, YJ,Dai, QS,et al. Feasibility of (99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas[J]. NUCLEAR SCIENCE AND TECHNIQUES,2008,19(2):105. |
| APA | Zhao, J.,Qi, YJ.,Dai, QS.,Zhang, XZ.,Qu, XM.,...&Liu, XD.(2008).Feasibility of (99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas.NUCLEAR SCIENCE AND TECHNIQUES,19(2),105. |
| MLA | Zhao, J,et al."Feasibility of (99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas".NUCLEAR SCIENCE AND TECHNIQUES 19.2(2008):105. |
入库方式： OAI收割
来源：上海应用物理研究所
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