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The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating
文献类型：期刊论文
| 作者 | Su, YY ; He, Y ; Lu, HT ; Sai, LM ; Li, QN（李晴暖） ; Li, WX（李文新） ; Wang, LH ; Shen, PP ; Huang, Q（黄庆） ; Fan, CH（樊春海） |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2009 |
| 卷号 | 30期号:1页码:19 |
| ISSN号 | 0142-9612 |
| 通讯作者 | Huang, Q (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Jialuo Rd 2019, Shanghai 201800, Peoples R China |
| 英文摘要 | In this report, we evaluated the cytotoxicity of a series of quantum dots (QDs) directly synthesized in aqueous phase, i.e., thiols-stabilized CdTe, CdTe/CdS core-shell structured and CdTe/CdS/ZnS core-shell-shell structured QDs, with a variety of cell lines including K562 and HEK293T. We have demonstrated that the CdTe QDs are highly toxic for cells due to the release of cadmium ions. Epitaxial growth of a CdS layer reduces the cytotoxicity of QDs to a small extent. However, the presence of a ZnS outlayer greatly improves the biocompatibility of QDs, with no observed cytotoxicity even at very high concentration and long-time exposure in cells. Our systematic investigation clearly shows that the cytotoxicity of QDs can be modulated through elaborate surface coatings and that the CdTe/CdS/ZnS core-shell-shell structured QDs directly synthesized in aqueous phase are highly promising biological fluorescent probes for cellular imaging. (C) 2008 Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering; Materials Science |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000261139100003 |
| 公开日期 | 2012-04-18 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/7855]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2004-2010年 |
| 推荐引用方式 GB/T 7714 | Su, YY,He, Y,Lu, HT,et al. The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating[J]. BIOMATERIALS,2009,30(1):19. |
| APA | Su, YY.,He, Y.,Lu, HT.,Sai, LM.,Li, QN.,...&Fan, CH.(2009).The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating.BIOMATERIALS,30(1),19. |
| MLA | Su, YY,et al."The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating".BIOMATERIALS 30.1(2009):19. |
入库方式： OAI收割
来源：上海应用物理研究所
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