The Origin of Nonmonotonic Complex Behavior and the Effects of Nonnative Interactions on the Diffusive Properties of Protein Folding
文献类型：期刊论文
| 作者 | Oliveira RJ ; Whitford PC ; Chahine J ; Wang J ; Onuchic JN ; Leite VBP |
| 刊名 | biophysical journal
 |
| 出版日期 | 2010 |
| 卷号 | 99期号:2页码:600-608 |
| 关键词 | COLD-SHOCK PROTEIN MOLECULAR-DYNAMICS SIMULATIONS TRANSITION-STATE ENERGY LANDSCAPE DEPENDENT DIFFUSION CONFORMATIONAL TRANSITIONS STRUCTURAL CORRELATIONS THERMOTOGA-MARITIMA UNFOLDING PATHWAYS ADENYLATE KINASE |
| ISSN号 | 0006-3495 |
| 通讯作者 | whitford pc |
| 中文摘要 | we present a method for calculating the configurational-dependent diffusion coefficient of a globular protein as a function of the global folding process. using a coarse-grained structure-based model, we determined the diffusion coefficient, in reaction coordinate space, as a function of the fraction of native contacts formed q for the cold shock protein (tmcsp). we find nonmonotonic behavior for the diffusion coefficient, with high values for the folded and unfolded ensembles and a lower range of values in the transition state ensemble. we also characterized the folding landscape associated with an energetically frustrated variant of the model. we find that a low-level of frustration can actually stabilize the native ensemble and increase the associated diffusion coefficient. these findings can be understood from a mechanistic standpoint, in that the transition state ensemble has a more homogeneous structural content when frustration is present. additionally, these findings are consistent with earlier calculations based on lattice models of protein folding and more recent single-molecule fluorescence measurements. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000280182300034 |
| 公开日期 | 2012-04-26 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/43587]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Oliveira RJ,Whitford PC,Chahine J,et al. The Origin of Nonmonotonic Complex Behavior and the Effects of Nonnative Interactions on the Diffusive Properties of Protein Folding[J]. biophysical journal,2010,99(2):600-608. |
| APA | Oliveira RJ,Whitford PC,Chahine J,Wang J,Onuchic JN,&Leite VBP.(2010).The Origin of Nonmonotonic Complex Behavior and the Effects of Nonnative Interactions on the Diffusive Properties of Protein Folding.biophysical journal,99(2),600-608. |
| MLA | Oliveira RJ,et al."The Origin of Nonmonotonic Complex Behavior and the Effects of Nonnative Interactions on the Diffusive Properties of Protein Folding".biophysical journal 99.2(2010):600-608. |
入库方式： OAI收割
来源：长春应用化学研究所
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