RELEASE OF IBUPROFEN FROM PEG-PLLA ELECTROSPUN FIBERS CONTAINING POLY(ETHYLENE GLYCOL)-b-POLY(alpha-HYDROXY OCTANOIC ACID) AS AN ADDITIVE
文献类型：期刊论文
| 作者 | Wang H ; Song HR ; Chen XS ; Deng YJ |
| 刊名 | chinese journal of polymer science
 |
| 出版日期 | 2010 |
| 卷号 | 28期号:3页码:417-425 |
| 关键词 | DELIVERY-SYSTEMS DRUG-DELIVERY BIODEGRADABLE POLYMERS BLOCK-COPOLYMERS ULTRAFINE FIBERS ACID) NANOPARTICLES MICELLES CELLS PLA |
| ISSN号 | 0256-7679 |
| 通讯作者 | deng yj |
| 中文摘要 | poly(alpha-hydroxy octanoic acid) was first used as an additive for the preparation of electrospun ultra-fine fibers of poly(ethylene glycol)-b-poly(l-lactide) (peg-plla). ibuprofen was loaded in the electrospun ultra-fine fibers. the results from environmental scanning electron microscopy (esem), wide angle x-ray diffraction (waxd) and differential scanning calorimetry (dsc) demonstrated that ibuprofen could be perfectly entrapped in the fibers electrospun from peg-plla using alpha-hydroxy octanoic acid or peg-b-poly(alpha-hydroxy octanoic acid) (peg-phoa) as additives. compared with electrospun peg-plla fibers which entrapped 20 wt% ibuprofen, the peg-plla electrospun fibers containing peg-phoa exhibited integral and robust after 1 week incubated in 37 degrees c, ph 7.4 phosphate buffer solution with 10 mu g/ml proteinase k. compared with electrospun fibers without peg-phoa, the concentration of proteinase k in release media had less effect on the release rate of ibuprofen. an unique release profile was found from peg-plla fiber after the incorporation of peg-phoa. enzyme degradation experiments demonstrated that peg-phoa but not alpha-hydroxy octanoic acid monomer was the crucial factor for integrity maintenance of the electrospun fibers, which may be due to the enzyme degradation tolerance property of the peg-phoa polymer additive. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000279111400015 |
| 公开日期 | 2012-04-26 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/43643]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang H,Song HR,Chen XS,et al. RELEASE OF IBUPROFEN FROM PEG-PLLA ELECTROSPUN FIBERS CONTAINING POLY(ETHYLENE GLYCOL)-b-POLY(alpha-HYDROXY OCTANOIC ACID) AS AN ADDITIVE[J]. chinese journal of polymer science,2010,28(3):417-425. |
| APA | Wang H,Song HR,Chen XS,&Deng YJ.(2010).RELEASE OF IBUPROFEN FROM PEG-PLLA ELECTROSPUN FIBERS CONTAINING POLY(ETHYLENE GLYCOL)-b-POLY(alpha-HYDROXY OCTANOIC ACID) AS AN ADDITIVE.chinese journal of polymer science,28(3),417-425. |
| MLA | Wang H,et al."RELEASE OF IBUPROFEN FROM PEG-PLLA ELECTROSPUN FIBERS CONTAINING POLY(ETHYLENE GLYCOL)-b-POLY(alpha-HYDROXY OCTANOIC ACID) AS AN ADDITIVE".chinese journal of polymer science 28.3(2010):417-425. |
入库方式： OAI收割
来源：长春应用化学研究所
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