Antibacterial effect of 317L stainless steel contained copper in prevention of implant-related infection in vitro and in vivo
文献类型：期刊论文
| 作者 | H. W. Chai ; L. Guo ; X. T. Wang ; Y. P. Fu ; J. L. Guan ; L. L. Tan ; L. Ren ; K. Yang |
| 刊名 | Journal of Materials Science-Materials in Medicine
 |
| 出版日期 | 2011 |
| 卷号 | 22期号:11页码:2525-2535 |
| 关键词 | resistant staphylococcus-aureus central venous catheters antimicrobial activity surfaces survival alloys bone osteomyelitis pathogens efficacy |
| ISSN号 | 0957-4530 |
| 中文摘要 | Bone and intramedullary bacterial infections are one of the most serious complications of the surgical repair of fractures. To reduce the incidence of implant-related infections, several biomaterial surface treatments with integrated antibiotics, antiseptics, or metal ions have been developed for implants. In this study, we evaluated the antibacterial activity and biocompatibility of 317L stainless steel containing 4.5% copper alloy (317L-Cu) in vitro and in vivo using an animal model. Common pathogens of implant-related infections are Staphylococcus aureus and Escherichia coli, which were injected into implant materials to study their antimicrobial potential. We compared antimicrobial potential of 317L-Cu with 317L stainless steel (317L) and titanium (Ti-6Al-4V) alloys as controls. Compared with controls, 317L-Cu materials inhibited colonization by both bacteria in vitro and in vivo. Compared with 317L and Ti-6Al-4V controls, 317L-Cu showed no significant difference in colony formation of osteoblast-like cells on metal surfaces after 72 h of incubation in vitro. Metal screws containing these materials were also made for our vivo study in a rabbit model. Tissue-implants were analyzed for infection and inflammatory changes by hematoxylin-eosin staining of implants in bone. The screw tract inflammation and infection of 317L-Cu was minimal, although some inflammatory cells gathered at acutely infected sites. In addition, after materials had been implanted for 14 days in vivo, the expression of insulin-like growth factor-1 (IGF-1) in osteoblasts around 317L-Cu screws tracts had increased compared with 317L and Ti-6Al-4V controls. Overall, 317L-Cu demonstrated strong antimicrobial activity and biocompatibility in vitro and in vivo and may be used as a biomaterial to reduce implant-related infections. |
| 原文出处 | |
| 公开日期 | 2012-04-13 |
| 源URL | [http://210.72.142.130/handle/321006/30245]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | H. W. Chai,L. Guo,X. T. Wang,et al. Antibacterial effect of 317L stainless steel contained copper in prevention of implant-related infection in vitro and in vivo[J]. Journal of Materials Science-Materials in Medicine,2011,22(11):2525-2535. |
| APA | H. W. Chai.,L. Guo.,X. T. Wang.,Y. P. Fu.,J. L. Guan.,...&K. Yang.(2011).Antibacterial effect of 317L stainless steel contained copper in prevention of implant-related infection in vitro and in vivo.Journal of Materials Science-Materials in Medicine,22(11),2525-2535. |
| MLA | H. W. Chai,et al."Antibacterial effect of 317L stainless steel contained copper in prevention of implant-related infection in vitro and in vivo".Journal of Materials Science-Materials in Medicine 22.11(2011):2525-2535. |
入库方式： OAI收割
来源：金属研究所
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